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Cimap3 Gene Detail
Summary
  • Symbol
    Cimap3
  • Name
    ciliary microtubule associated protein 3
  • Synonyms
    1700027A23Rik, Pifo, pitchfork
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923670
    NCBI Gene: 100503311
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105904273-105921962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.47 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923670
 protein coding gene Chr3:105904273-105921962 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027727
 protein coding gene Chr3:107385939-107406216 (-)
A/J MGP_AJ_G0027687
 protein coding gene Chr3:103952468-103971307 (-)
AKR/J MGP_AKRJ_G0027652
 protein coding gene Chr3:106529949-106549089 (-)
BALB/cJ MGP_BALBcJ_G0027699
 protein coding gene Chr3:103733973-103753870 (-)
C3H/HeJ MGP_C3HHeJ_G0027429
 protein coding gene Chr3:106878166-106896243 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028143
 protein coding gene Chr3:111391937-111411560 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025483
 protein coding gene Chr3:100026588-100047175 (-)
CAST/EiJ MGP_CASTEiJ_G0026885
 protein coding gene Chr3:106031693-106053015 (-)
CBA/J MGP_CBAJ_G0027404
 protein coding gene Chr3:115153317-115168986 (-)
DBA/2J MGP_DBA2J_G0027546
 protein coding gene Chr3:103196693-103215227 (-)
FVB/NJ MGP_FVBNJ_G0027514
 protein coding gene Chr3:101120129-101138415 (-)
LP/J MGP_LPJ_G0027653
 protein coding gene Chr3:108788091-108807704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027544
 protein coding gene Chr3:121265445-121279816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028198
 protein coding gene Chr3:106104047-106127690 (-)
PWK/PhJ MGP_PWKPhJ_G0026611
 protein coding gene Chr3:102978711-102998411 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026432
 protein coding gene Chr3:104109006-104130367 (-)
WSB/EiJ MGP_WSBEiJ_G0026965
 protein coding gene Chr3:106639903-106662316 (-)



Homology
more
  • Human Ortholog
    CIMAP3, ciliary microtubule associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIMAP3, ciliary microtubule associated protein 3
  • Synonyms
    C1orf88, PIFO, pitchfork
  • Links
    NCBI Gene ID: 128344
    neXtProt AC: NX_Q8TCI5
    UniProt: Q8TCI5

  • Chr Location
    1p13.2; chr1:111324663-111353017 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous null embryos generated by tetraploid complementation display embryonic lethality with double outlet heart right ventricle, duplicated cilia and defects in cilia disassembly. A conditional allele activated in limb bub cultures doesn't interfere with cilia development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    23
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100503311 NCBI Gene Model | MGI Sequence Detail 17690 C57BL/6J ±  kb
    transcript NM_001200028 RefSeq | MGI Sequence Detail 973 C57BL/6  
    polypeptide Q9D9W1 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313583 Xiong Y, et al., Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling. Elife. 2020 Nov 17;9:e56914
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory