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Gucy2c Gene Detail
Summary
  • Symbol
    Gucy2c
  • Name
    guanylate cyclase 2c
  • Synonyms
    GC-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:106903
    NCBI Gene: 14917
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136674282-136758740 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106903
 protein coding gene Chr6:136674282-136758763 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031424
 protein coding gene Chr6:141139001-141229165 (-)
A/J MGP_AJ_G0031400
 protein coding gene Chr6:135546952-135626971 (-)
AKR/J MGP_AKRJ_G0031327
 protein coding gene Chr6:139674239-139755259 (-)
BALB/cJ MGP_BALBcJ_G0031407
 protein coding gene Chr6:135426310-135507997 (-)
C3H/HeJ MGP_C3HHeJ_G0031128
 protein coding gene Chr6:139711338-139790361 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031867
 protein coding gene Chr6:145013223-145108128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028998
 protein coding gene Chr6:134710515-134792394 (-)
CAST/EiJ MGP_CASTEiJ_G0030497
 protein coding gene Chr6:139204486-139298361 (-)
CBA/J MGP_CBAJ_G0031087
 protein coding gene Chr6:150393390-150496038 (-)
DBA/2J MGP_DBA2J_G0031245
 protein coding gene Chr6:134417055-134496102 (-)
FVB/NJ MGP_FVBNJ_G0031195
 protein coding gene Chr6:133323018-133410680 (-)
LP/J MGP_LPJ_G0031329
 protein coding gene Chr6:141264464-141348400 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031235
 protein coding gene Chr6:154289516-154380999 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031899
 protein coding gene Chr6:139439247-139522925 (-)
PWK/PhJ MGP_PWKPhJ_G0030223
 protein coding gene Chr6:132930410-133020827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030046
 protein coding gene Chr6:137691244-137781878 (-)
WSB/EiJ MGP_WSBEiJ_G0030588
 protein coding gene Chr6:140063910-140148501 (-)



Homology
more
  • Human Ortholog
    GUCY2C, guanylate cyclase 2C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCY2C, guanylate cyclase 2C
  • Synonyms
    DIAR6, GCC, GC-C, GUC2C, HSER, MECIL, MUCIL, STAR
  • Links
    NCBI Gene ID: 2984
    neXtProt AC: NX_P25092
    UniProt: P25092

  • Chr Location
    12p12.3; chr12:14612632-14696599 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gucy2c mouse models; 1 with human GUCY2C associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    117
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14917 NCBI Gene Model | MGI Sequence Detail 84459 C57BL/6J ±  kb
    transcript NM_001127318 RefSeq | MGI Sequence Detail 3951 ZRU/MplStud  
    polypeptide Q3UWA6 UniProt | EBI | MGI Sequence Detail 1072 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 19
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35363, MGI:2141513
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
    • Latest
      J:337523 Barton JR, et al., Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest. 2023 Feb 15;133(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory