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Lgi1 Gene Detail
Summary
  • Symbol
    Lgi1
  • Name
    leucine-rich repeat LGI family, member 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861691
    NCBI Gene: 56839
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38253135-38297387 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861691
 protein coding gene Chr19:38252984-38300662 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025091
 protein coding gene Chr19:37303152-37356654 (+)
A/J MGP_AJ_G0025067
 protein coding gene Chr19:35486139-35535022 (+)
AKR/J MGP_AKRJ_G0025035
 protein coding gene Chr19:36689565-36739295 (+)
BALB/cJ MGP_BALBcJ_G0025065
 protein coding gene Chr19:35596463-35646590 (+)
C3H/HeJ MGP_C3HHeJ_G0024824
 protein coding gene Chr19:36767886-36818008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025506
 protein coding gene Chr19:38364782-38417622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022925
 protein coding gene Chr19:34848363-34892926 (+)
CAST/EiJ MGP_CASTEiJ_G0024291
 protein coding gene Chr19:36641544-36695610 (+)
CBA/J MGP_CBAJ_G0024801
 protein coding gene Chr19:40155477-40213699 (+)
DBA/2J MGP_DBA2J_G0024933
 protein coding gene Chr19:35342423-35391809 (+)
FVB/NJ MGP_FVBNJ_G0024894
 protein coding gene Chr19:35163123-35211691 (+)
LP/J MGP_LPJ_G0025019
 protein coding gene Chr19:37399686-37448813 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024925
 protein coding gene Chr19:39940246-39992251 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025564
 protein coding gene Chr19:36792137-36845502 (+)
PWK/PhJ MGP_PWKPhJ_G0024043
 protein coding gene Chr19:35207832-35257898 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023843
 protein coding gene Chr19:35630713-35678290 (+)
WSB/EiJ MGP_WSBEiJ_G0024358
 protein coding gene Chr19:36878068-36938957 (+)



Homology
more
  • Human Ortholog
    LGI1, leucine rich glioma inactivated 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGI1, leucine rich glioma inactivated 1
  • Synonyms
    ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
  • Links
    NCBI Gene ID: 9211
    neXtProt AC: NX_O95970
    UniProt: O95970

  • Chr Location
    10q23.33; chr10:93757840-93806272 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lgi1 mouse models; 1 with human LGI1 associations

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 5 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    875
  • Tissues
    22
  • cDNA Data
    4
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56839 NCBI Gene Model | MGI Sequence Detail 44253 C57BL/6J ±  kb
    transcript NR_157558 RefSeq | MGI Sequence Detail 4389 C57BL/6  
    polypeptide Q9JIA1 UniProt | EBI | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 6
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147767
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
    • Latest
      J:345940 Miyazaki Y, et al., Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Rep. 2024 Jan 23;43(1):113634
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory