About   Help   FAQ
Nmt2 Gene Detail
Summary
  • Symbol
    Nmt2
  • Name
    N-myristoyltransferase 2
  • Synonyms
    A930001K02Rik, hNMT-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202298
    NCBI Gene: 18108
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3285249-3329914 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 1.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202298
 protein coding gene Chr2:3285249-3329914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025303
 protein coding gene Chr2:240329-292894 (+)
A/J MGP_AJ_G0025279
 protein coding gene Chr2:239406-284929 (+)
AKR/J MGP_AKRJ_G0025248
 protein coding gene Chr2:229383-284742 (+)
BALB/cJ MGP_BALBcJ_G0025275
 protein coding gene Chr2:217802-265665 (+)
C3H/HeJ MGP_C3HHeJ_G0025035
 protein coding gene Chr2:250054-298115 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025718
 protein coding gene Chr2:235512-280896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023132
 protein coding gene Chr2:191588-234824 (+)
CAST/EiJ MGP_CASTEiJ_G0024499
 protein coding gene Chr2:235365-282685 (+)
CBA/J MGP_CBAJ_G0025015
 protein coding gene Chr2:264605-310579 (+)
DBA/2J MGP_DBA2J_G0025146
 protein coding gene Chr2:218656-263284 (+)
FVB/NJ MGP_FVBNJ_G0025108
 protein coding gene Chr2:236353-280735 (+)
LP/J MGP_LPJ_G0025233
 protein coding gene Chr2:253516-302074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025141
 protein coding gene Chr2:245831-291950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025776
 protein coding gene Chr2:244578-298507 (+)
PWK/PhJ MGP_PWKPhJ_G0024248
 protein coding gene Chr2:219668-266486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024050
 protein coding gene Chr2:248925-302530 (+)
WSB/EiJ MGP_WSBEiJ_G0024569
 protein coding gene Chr2:247879-295180 (+)



Homology
more
  • Human Ortholog
    NMT2, N-myristoyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMT2, N-myristoyltransferase 2
  • Links
    NCBI Gene ID: 9397
    neXtProt AC: NX_O60551
    UniProt: O60551

  • Chr Location
    10p13; chr10:15102584-15168693 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    20
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18108 NCBI Gene Model | MGI Sequence Detail 44666 C57BL/6J ±  kb
    transcript NM_008708 RefSeq | MGI Sequence Detail 4461 C57BL/6  
    polypeptide O70311 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011294 glycylpeptide N-tetradecanoyltransferase 2
      (term hierarchy)
    • EC
      2.3.1.97
    • InterPro Domains
      IPR016181 Acyl-CoA N-acyltransferase
      IPR000903 Glycylpeptide N-tetradecanoyltransferase
      IPR022678 Glycylpeptide N-tetradecanoyltransferase, conserved site
      IPR022677 Glycylpeptide N-tetradecanoyltransferase, C-terminal
      IPR022676 Glycylpeptide N-tetradecanoyltransferase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139017, MGI:2139218, MGI:2445147
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:46538 Giang DK, et al., A second mammalian N-myristoyltransferase. J Biol Chem. 1998 Mar 20;273(12):6595-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory