Pebp4 MGI Mouse Gene Detail - MGI:1920773 - phosphatidylethanolamine binding protein 4

Symbol

Pebp4
Name

phosphatidylethanolamine binding protein 4
Synonyms

1700051A02Rik, 1700081D17Rik

Feature Type

protein coding gene
IDs

MGI:1920773
NCBI Gene: 73523
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:70077869-70297367 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.10 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920773	protein coding gene	Chr14:70077856-70297367 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021527	protein coding gene	Chr14:64439911-64678928 (+)
A/J	MGP_AJ_G0021486	protein coding gene	Chr14:63099658-63322406 (+)
AKR/J	MGP_AKRJ_G0021462	protein coding gene	Chr14:64990843-65221420 (+)
BALB/cJ	MGP_BALBcJ_G0021492	protein coding gene	Chr14:62860886-63083127 (+)
C3H/HeJ	MGP_C3HHeJ_G0021269	protein coding gene	Chr14:64705229-64928815 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021931	protein coding gene	Chr14:67343772-67595969 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019471	protein coding gene	Chr14:60931495-61158543 (+)
CAST/EiJ	MGP_CASTEiJ_G0020786	protein coding gene	Chr14:61270200-61514274 (+)
CBA/J	MGP_CBAJ_G0021236	protein coding gene	Chr14:69450722-69706025 (+)
DBA/2J	MGP_DBA2J_G0021359	protein coding gene	Chr14:62479836-62703600 (+)
FVB/NJ	MGP_FVBNJ_G0021338	protein coding gene	Chr14:61911360-62132443 (+)
LP/J	MGP_LPJ_G0021430	protein coding gene	Chr14:65700871-65932989 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021367	protein coding gene	Chr14:68382952-68625846 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021955	protein coding gene	Chr14:64253246-64482747 (+)
PWK/PhJ	MGP_PWKPhJ_G0020530	protein coding gene	Chr14:59236806-59465061 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020363	protein coding gene	Chr14:60172401-60407004 (+)
WSB/EiJ	MGP_WSBEiJ_G0020839	protein coding gene	Chr14:64551027-64788248 (+)

Human Ortholog

PEBP4, phosphatidylethanolamine binding protein 4

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PEBP4, phosphatidylethanolamine binding protein 4
Synonyms

CORK1, CORK-1, GWTM1933, HEL-S-300, hPEBP4, PEBP-4, PRO4408
Links

HGNC:28319

NCBI Gene ID: 157310

neXtProt AC: NX_Q96S96

UniProt: Q96S96
Chr Location

8p21.3; chr8:22713251-23000000 (-) GRCh38

MGI Vertebrate Homology

Pebp4 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: PEBP4
Gene Tree

Pebp4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

11
Targeted

3
Genomic Mutations

1 involving Pebp4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

15
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pebp4

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All Sequences

33
RefSeq

4
UniProt

2
CCDS

CCDS27245.1

Ensembl

ENSMUSG00000022085 (Evidence)
NCBI Gene

73523

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022085	Ensembl Gene Model \| MGI Sequence Detail	219499	C57BL/6J	± kb
transcript	ENSMUST00000022678	Ensembl \| MGI Sequence Detail	1079	Not Applicable
polypeptide	ENSMUSP00000022678	Ensembl \| MGI Sequence Detail	242	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012533 phosphatidylethanolamine-binding protein 4

(term hierarchy)
InterPro Domains

IPR036610 PEBP-like superfamily

IPR001858 Phosphatidylethanolamine-binding, conserved site

IPR008914 Phosphatidylethanolamine-binding protein

IPR035810 Phosphatidylethanolamine-binding protein, eukaryotic

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All nucleic 15

cDNA 15

Microarray probesets 4

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MGI:1920634, MGI:2145638

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347873 Shi QQ, et al., PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway. Cell Mol Life Sci. 2024 Mar 13;81(1):133

TSS for Pebp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126381	Chr14:70077808-70077827 (+)	-51 bp
Tssr4467	Chr14:70077836-70077840 (+)	-31 bp
Tssr126382	Chr14:70077842-70077914 (+)	9 bp
Tssr126383	Chr14:70077915-70077926 (+)	52 bp
Tssr126384	Chr14:70077927-70077930 (+)	60 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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