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Plxnb2 Gene Detail
Summary
  • Symbol
    Plxnb2
  • Name
    plexin B2
  • Synonyms
    1110007H23Rik, Debt, mKIAA0315
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154239
    NCBI Gene: 140570
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89039752-89064960 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.68 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154239
 protein coding gene Chr15:89039752-89064991 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022221
 protein coding gene Chr15:90330147-90356623 (-)
A/J MGP_AJ_G0022180
 protein coding gene Chr15:86880231-86905373 (-)
AKR/J MGP_AKRJ_G0022155
 protein coding gene Chr15:89445368-89470479 (-)
BALB/cJ MGP_BALBcJ_G0022186
 protein coding gene Chr15:86981250-87006436 (-)
C3H/HeJ MGP_C3HHeJ_G0021956
 protein coding gene Chr15:89434242-89459439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022631
 protein coding gene Chr15:93611600-93636912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020156
 protein coding gene Chr15:83102253-83128103 (-)
CAST/EiJ MGP_CASTEiJ_G0021478
 protein coding gene Chr15:90219097-90246008 (-)
CBA/J MGP_CBAJ_G0021923
 protein coding gene Chr15:96776546-96804395 (-)
DBA/2J MGP_DBA2J_G0022050
 protein coding gene Chr15:86331659-86356842 (-)
FVB/NJ MGP_FVBNJ_G0022029
 protein coding gene Chr15:85396022-85422415 (-)
LP/J MGP_LPJ_G0022121
 protein coding gene Chr15:90488623-90513789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022049
 protein coding gene Chr15:101199765-101225621 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022646
 protein coding gene Chr15:89480835-89507199 (-)
PWK/PhJ MGP_PWKPhJ_G0021219
 protein coding gene Chr15:86376210-86401951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021053
 protein coding gene Chr15:89214347-89239910 (-)
WSB/EiJ MGP_WSBEiJ_G0021527
 protein coding gene Chr15:89969990-89995330 (-)



Homology
more
  • Human Ortholog
    PLXNB2, plexin B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNB2, plexin B2
  • Synonyms
    dJ402G11.3, lncFAL, MM1, Nbla00445, PLEXB2
  • Links
    NCBI Gene ID: 23654
    neXtProt AC: NX_O15031
    UniProt: O15031

  • Chr Location
    22q13.33; chr22:50274979-50307646 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 6 alleles in 10 genetic backgrounds
    20 phenotypes from multigenic genotypes
    4 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1015
  • Tissues
    143
  • cDNA Data
    393
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140570 NCBI Gene Model | MGI Sequence Detail 25209 C57BL/6J ±  kb
    transcript NM_001416431 RefSeq | MGI Sequence Detail 6685 ZRU/MplStud  
    polypeptide B2RXS4 UniProt | EBI | MGI Sequence Detail 1842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 400
      cDNA 395
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37143, MGI:108106, MGI:1921090
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 11
      Phenotypes 53
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345627 Adel SS, et al., Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation. Mol Cell Neurosci. 2024 Feb 6;128:103920
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory