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Rab37 Gene Detail
Summary
  • Symbol
    Rab37
  • Name
    RAB37, member RAS oncogene family
  • Synonyms
    B230331O03Rik, B230354I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929945
    NCBI Gene: 58222
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:114982257-115053062 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.59 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    497 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929945
 protein coding gene Chr11:114982257-115053066 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019371
 protein coding gene Chr11:119089155-119162669 (+)
A/J MGP_AJ_G0019340
 protein coding gene Chr11:113891489-113962909 (+)
AKR/J MGP_AKRJ_G0019310
 protein coding gene Chr11:117287018-117363053 (+)
BALB/cJ MGP_BALBcJ_G0019314
 protein coding gene Chr11:114311371-114380792 (+)
C3H/HeJ MGP_C3HHeJ_G0019120
 protein coding gene Chr11:117641235-117714490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019764
 protein coding gene Chr11:122723273-122800687 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017386
 protein coding gene Chr11:110936576-111006730 (+)
CAST/EiJ MGP_CASTEiJ_G0018675
 protein coding gene Chr11:118939153-119020864 (+)
CBA/J MGP_CBAJ_G0019092
 protein coding gene Chr11:127563383-127646920 (+)
DBA/2J MGP_DBA2J_G0019203
 protein coding gene Chr11:113331896-113403015 (+)
FVB/NJ MGP_FVBNJ_G0019195
 protein coding gene Chr11:112801343-112873884 (+)
LP/J MGP_LPJ_G0019273
 protein coding gene Chr11:119465527-119542004 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019228
 protein coding gene Chr11:126758246-126831540 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019802
 protein coding gene Chr11:117949359-118021353 (+)
PWK/PhJ MGP_PWKPhJ_G0018439
 protein coding gene Chr11:114606665-114678738 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018231
 protein coding gene Chr11:117701387-117768951 (+)
WSB/EiJ MGP_WSBEiJ_G0018727
 protein coding gene Chr11:117892101-117964243 (+)



Homology
more
  • Human Ortholog
    RAB37, RAB37, member RAS oncogene family
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB37, RAB37, member RAS oncogene family
  • Links
    NCBI Gene ID: 326624
    neXtProt AC: NX_Q96AX2
    UniProt: Q96AX2

  • Chr Location
    17q25.1; chr17:74670578-74747335 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced insulin secretion even under high glucose conditions and hyperglycemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    6
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020732 Ensembl Gene Model | MGI Sequence Detail 70806 C57BL/6J ±  kb
    transcript ENSMUST00000021076 Ensembl | MGI Sequence Detail 2210 Not Applicable  
    polypeptide ENSMUSP00000021076 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442158, MGI:3041187
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:61135 Masuda ES, et al., Rab37 is a novel mast cell specific GTPase localized to secretory granules. FEBS Lett. 2000 Mar 17;470(1):61-4
    • Latest
      J:334080 Wu SY, et al., Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2023 Apr;19(4):1239-1257
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/07/2024
    MGI 6.23     		The Jackson Laboratory