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Sftpa1 Gene Detail
Summary
  • Symbol
    Sftpa1
  • Name
    surfactant associated protein A1
  • Synonyms
    Sftp1, Sftp-1, SFTPA1, SP-A, surfactant pulmonary associated protein A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109518
    NCBI Gene: 20387
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:40853745-40858330 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.36 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109518
 protein coding gene Chr14:40853739-40858409 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021197
 protein coding gene Chr14:34763360-34768030 (+)
A/J MGP_AJ_G0021145
 protein coding gene Chr14:33415776-33420446 (+)
AKR/J MGP_AKRJ_G0021122
 protein coding gene Chr14:34782107-34786777 (+)
BALB/cJ MGP_BALBcJ_G0021149
 protein coding gene Chr14:33634210-33638880 (+)
C3H/HeJ MGP_C3HHeJ_G0020932
 protein coding gene Chr14:34743899-34748569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021581
 protein coding gene Chr14:36161275-36165945 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019143
 protein coding gene Chr14:33036870-33041095 (+)
CAST/EiJ MGP_CASTEiJ_G0020457
 protein coding gene Chr14:34513514-34518182 (+)
CBA/J MGP_CBAJ_G0020898
 protein coding gene Chr14:37390457-37395127 (+)
DBA/2J MGP_DBA2J_G0021021
 protein coding gene Chr14:33375532-33380202 (+)
FVB/NJ MGP_FVBNJ_G0021005
 protein coding gene Chr14:33312328-33316998 (+)
LP/J MGP_LPJ_G0021090
 protein coding gene Chr14:35000584-35005290 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021031
 protein coding gene Chr14:37014184-37018854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021614
 protein coding gene Chr14:34566215-34570921 (+)
PWK/PhJ MGP_PWKPhJ_G0020205
 protein coding gene Chr14:32846235-32850903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020029
 protein coding gene Chr14:34190496-34195376 (+)
WSB/EiJ MGP_WSBEiJ_G0020512
 protein coding gene Chr14:34681404-34686074 (+)



Homology
more
  • Human Ortholog
    SFTPA1, surfactant protein A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFTPA1, surfactant protein A1
  • Synonyms
    COLEC4, ILD1, PSAP, PSPA, PSP-A, SFTP1, SFTPA1B, SPA, SP-A, SPA1, SP-A1, SP-A1 beta, SP-A1 delta, SP-A1 epsilon, SP-A1 gamma
  • Links
    NCBI Gene ID: 653509
    neXtProt AC: NX_Q8IWL2
    UniProt: Q8IWL2

  • Chr Location
    10q22.3; chr10:79610939-79615455 (+)  GRCh38
  • Human Ortholog
    SFTPA2, surfactant protein A2
  • Synonyms
    COLEC5, ILD2, PSAP, PSPA, PSP-A, SFTP1, SFTPA2B, SP-2A, SP-A, SPA2, SPAII
  • Links
    NCBI Gene ID: 729238
    neXtProt AC: NX_Q8IWL1
    UniProt: Q8IWL1

  • Chr Location
    10q22.3; chr10:79555852-79560407 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human SFTPA1,SFTPA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired lung response to hyperventilation, reduced resistance to pulmonary infections, and enhanced pulmonary inflammatory response to lipopolysaccharide.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    37
  • cDNA Data
    31
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20387 NCBI Gene Model | MGI Sequence Detail 4586 C57BL/6J ±  kb
    transcript NM_023134 RefSeq | MGI Sequence Detail 2775 ZRU/MplStud  
    polypeptide P35242 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 8
      cDNA 34
      Primer pair 11
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14377, MGD-MRK-14380, MGD-MRK-39517
    References
    more
    • Summaries
      All 285
      Developmental Gene Expression 110
      Gene Ontology 5
      Phenotypes 119
    • Earliest
      J:44870 Ten Have-Opbroek AA, Lung development in the mouse embryo. Exp Lung Res. 1991 Mar-Apr;17(2):111-30
    • Latest
      J:345129 Bachor TP, et al., Identification of AgRP cells in the murine hindbrain that drive feeding. Mol Metab. 2024 Feb;80:101886
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory