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Sub1 Gene Detail
Summary
  • Symbol
    Sub1
  • Name
    SUB1 homolog, transcriptional regulator
  • Synonyms
    P15, Pc4, Rpo2tc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104811
    NCBI Gene: 20024
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:11981422-11996091 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.90 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104811
 protein coding gene Chr15:11981422-11997069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021733
 protein coding gene Chr15:9200922-9215637 (-)
A/J MGP_AJ_G0021693
 protein coding gene Chr15:8910927-8925649 (-)
AKR/J MGP_AKRJ_G0021671
 protein coding gene Chr15:9140882-9155567 (-)
BALB/cJ MGP_BALBcJ_G0021700
 protein coding gene Chr15:8808655-8824299 (-)
C3H/HeJ MGP_C3HHeJ_G0021476
 protein coding gene Chr15:9100847-9116491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022139
 protein coding gene Chr15:9533553-9549197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019676
 protein coding gene Chr15:8360200-8376084 (-)
CAST/EiJ MGP_CASTEiJ_G0020992
 protein coding gene Chr15:9188097-9203739 (-)
CBA/J MGP_CBAJ_G0021445
 protein coding gene Chr15:9806942-9821627 (-)
DBA/2J MGP_DBA2J_G0021569
 protein coding gene Chr15:8763749-8778434 (-)
FVB/NJ MGP_FVBNJ_G0021547
 protein coding gene Chr15:8624941-8640576 (-)
LP/J MGP_LPJ_G0021637
 protein coding gene Chr15:9128077-9142798 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021572
 protein coding gene Chr15:10056240-10071877 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022162
 protein coding gene Chr15:9146663-9158493 (-)
PWK/PhJ MGP_PWKPhJ_G0020735
 protein coding gene Chr15:8954182-8969938 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020573
 protein coding gene Chr15:9081226-9096891 (-)
WSB/EiJ MGP_WSBEiJ_G0021048
 protein coding gene Chr15:9137662-9153300 (-)



Homology
more
  • Human Ortholog
    SUB1, SUB1 regulator of transcription
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUB1, SUB1 regulator of transcription
  • Synonyms
    p14, P15, PC4
  • Links
    NCBI Gene ID: 10923
    neXtProt AC: NX_P53999
    UniProt: P53999

  • Chr Location
    5p13.3; chr5:32531633-32604079 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO is embryonic lethal. Conditional KO in the brain increases sensitivity of hippocampal neurons to hypoxia, causing changes in movement, activity and spatial memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    159
  • cDNA Data
    18
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20024 NCBI Gene Model | MGI Sequence Detail 14670 C57BL/6J ±  kb
transcript NM_001411715 RefSeq | MGI Sequence Detail 3326 C57BL/6  
polypeptide P11031 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015810 activated RNA polymerase II transcriptional coactivator p15
    (term hierarchy)
  • InterPro Domains
    IPR045125 RNA polymerase II transcriptional coactivator Sub1/Tcp4-like
    IPR009044 ssDNA-binding transcriptional regulator
    IPR003173 Transcriptional coactivator p15 (PC4), C-terminal
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28105, MGI:2146069
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:25189 Ballard DW, et al., Identification of a novel 9-kDa polypeptide from nuclear extracts. DNA binding properties, primary structure, and in vitro expression. J Biol Chem. 1988 Jun 15;263(17):8450-7
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory