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Sulf2 Gene Detail
Summary
  • Symbol
    Sulf2
  • Name
    sulfatase 2
  • Synonyms
    2010004N24Rik, mKIAA1247
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919293
    NCBI Gene: 72043
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165915819-165997603 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 86.31 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    560 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919293
 protein coding gene Chr2:165915009-165997603 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026900
 protein coding gene Chr2:171704549-171790860 (-)
A/J MGP_AJ_G0026866
 protein coding gene Chr2:164642887-164724567 (-)
AKR/J MGP_AKRJ_G0026839
 protein coding gene Chr2:169555210-169640576 (-)
BALB/cJ MGP_BALBcJ_G0026875
 protein coding gene Chr2:165004724-165087458 (-)
C3H/HeJ MGP_C3HHeJ_G0026619
 protein coding gene Chr2:169907204-169998608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027323
 protein coding gene Chr2:176682200-176773507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024695
 protein coding gene Chr2:158020759-158103110 (-)
CAST/EiJ MGP_CASTEiJ_G0026077
 protein coding gene Chr2:170277419-170427967 (-)
CBA/J MGP_CBAJ_G0026596
 protein coding gene Chr2:183141972-183241888 (-)
DBA/2J MGP_DBA2J_G0026732
 protein coding gene Chr2:163791003-163874200 (-)
FVB/NJ MGP_FVBNJ_G0026700
 protein coding gene Chr2:162261681-162344738 (-)
LP/J MGP_LPJ_G0026834
 protein coding gene Chr2:171721646-171808832 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026719
 protein coding gene Chr2:186591324-186676598 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027379
 protein coding gene Chr2:169455677-169541585 (-)
PWK/PhJ MGP_PWKPhJ_G0025812
 protein coding gene Chr2:163411934-163495392 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025614
 protein coding gene Chr2:168379045-168476579 (-)
WSB/EiJ MGP_WSBEiJ_G0026148
 protein coding gene Chr2:170354517-170445449 (-)



Homology
more
  • Human Ortholog
    SULF2, sulfatase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SULF2, sulfatase 2
  • Synonyms
    HSULF-2
  • Links
    NCBI Gene ID: 55959
    neXtProt AC: NX_Q8IWU5
    UniProt: Q8IWU5

  • Chr Location
    20q13.12; chr20:47656197-47786627 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 6 alleles in 8 genetic backgrounds
    53 phenotypes from multigenic genotypes
    3 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene may lead to a partially penetrant, strain-dependent phenotype of embryonic lethality, reduced postnatal body weight, lung abnormalities, brain malformations, and reduced fertility. Mice homozygous for a hypomorphic gene-trap allele display skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    136
  • cDNA Data
    24
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72043 NCBI Gene Model | MGI Sequence Detail 81785 C57BL/6J ±  kb
    transcript NM_001355619 RefSeq | MGI Sequence Detail 4001 C57BL/6  
    polypeptide Q8CFG0 UniProt | EBI | MGI Sequence Detail 875 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 26
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139186
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:342037 Tsuji Y, et al., Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magn Reson Imaging. 2022 May;88:123-131
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory