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Thap11 Gene Detail
Summary
  • Symbol
    Thap11
  • Name
    THAP domain containing 11
  • Synonyms
    2810036E22Rik, CTG-B45d, Ronin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930964
    NCBI Gene: 59016
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106581764-106583582 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.05 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930964
 protein coding gene Chr8:106581735-106583582 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034062
 protein coding gene Chr8:108173631-108175478 (+)
A/J MGP_AJ_G0034043
 protein coding gene Chr8:103847141-103848988 (+)
AKR/J MGP_AKRJ_G0033969
 protein coding gene Chr8:106849112-106850959 (+)
BALB/cJ MGP_BALBcJ_G0034036
 protein coding gene Chr8:104035193-104037040 (+)
C3H/HeJ MGP_C3HHeJ_G0033748
 protein coding gene Chr8:107592941-107594788 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034556
 protein coding gene Chr8:112145520-112147367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031498
 protein coding gene Chr8:96988715-96990568 (+)
CAST/EiJ MGP_CASTEiJ_G0033074
 protein coding gene Chr8:107107816-107109663 (+)
CBA/J MGP_CBAJ_G0033721
 protein coding gene Chr8:115749789-115751636 (+)
DBA/2J MGP_DBA2J_G0033876
 protein coding gene Chr8:103193861-103195708 (+)
FVB/NJ MGP_FVBNJ_G0033822
 protein coding gene Chr8:102124685-102126532 (+)
LP/J MGP_LPJ_G0033967
 protein coding gene Chr8:108384077-108385924 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033865
 protein coding gene Chr8:118944871-118946718 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034574
 protein coding gene Chr8:106816200-106818047 (+)
PWK/PhJ MGP_PWKPhJ_G0032775
 protein coding gene Chr8:102596934-102598781 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032616
 protein coding gene Chr8:105506717-105508564 (+)
WSB/EiJ MGP_WSBEiJ_G0033190
 protein coding gene Chr8:107502493-107504340 (+)



Homology
more
  • Human Ortholog
    THAP11, THAP domain containing 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THAP11, THAP domain containing 11
  • Synonyms
    CTG-B43a, CTG-B45d, HRIHFB2206, RONIN
  • Links
    NCBI Gene ID: 57215
    neXtProt AC: NX_Q96EK4
    UniProt: Q96EK4

  • Chr Location
    16q22.1; chr16:67842320-67844195 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thap11 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to peri-implantation lethality and defects in the inner cell mass. Homozygous null ES cells are not viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    21
  • cDNA Data
    74
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036442 Ensembl Gene Model | MGI Sequence Detail 1819 C57BL/6J ±  kb
    transcript ENSMUST00000040445 Ensembl | MGI Sequence Detail 1819 Not Applicable  
    polypeptide ENSMUSP00000048994 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 74
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924091
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:317822 Chern T, et al., Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/07/2024
    MGI 6.23     		The Jackson Laboratory