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EMAGE:3595

Lmo3 LIM domain only 3 ( MGI:102810)
TS20 (12.5 dpc)
in situ hybridisation

Data Images
EMAGE:3595
Fig5g.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(00)00515-3] Mech Dev 100: 165-75, Bulchand S; Grove EA; Porter FD; Tole S, LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Copyright 2001

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:3595EMAGE:3595Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mappingspatial mapping

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
3595_voxel_strong_3D_1.wlz
3595_voxel_moderate_3D_1.wlz
3595_voxel_weak_3D_1.wlz
3595_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:3595_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
telencephalon
detected detected
regionalExpression in entire lateral, and some of medial, telencephalic neuroepithelium; does not continue to boundary with cortical hem
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:2386904
Entity Detected:Lmo3, LIM domain only 3 ( MGI:102810)
Notes:The Lmo3 probe used in this study by Bulchand et al, 2001 [PMID:11165475] is described as such: "Digoxigenin-labeled probes were generated using T3, T7 or SP6 RNA polymerases from plasmids containing fragments of the appropriate genes, as described previously ( Tole [PMID:9362459] ; Tole [PMID:10625551] and Grove [PMID:9584130] )". Editor's Note: none of these three references mention a Lmo3 (Rbtn-3/Rbtn3) probe.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:12.5 dpc
Theiler Stage:TS20
Mutations:none (wild-type)
Preparation:section
Procedures
Fixation:4% paraformaldehyde
Embedding:cryosection
General Information
Authors:Bulchand S; Grove EA; Porter FD; Tole S (2001) [PMID:11165475] . Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/S0925-4773(00)00515-3] [ PMID:11165475] Bulchand S, Grove EA, Porter FD, Tole S 2001 LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev (100):165-75
 [ PMID:9362459] Tole S, Christian C, Grove EA 1997 Early specification and autonomous development of cortical fields in the mouse hippocampus. Development (124):4959-70
 [ doi:10.1006/dbio.1999.9509] [ PMID:10625551] Tole S, Ragsdale CW, Grove EA 2000 Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol (217):254-65
 [ PMID:9584130] Grove EA, Tole S, Limon J, Yip L, Ragsdale CW 1998 The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development (125):2315-25
Links:MGI:2386932 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI