EMAGE mouse gene expression spatial database

EMAGE:1032

Bmp2 bone morphogenetic protein 2 ( MGI:88177)
TS12 (6-8 Somite no.)
in situ hybridisation

Data Images


Figure 7C of Kanzler et al., 2000 [PMID:10662648] . Copyright: This image is from Development and is displayed with permission of The Company of Biologists Ltd. who owns the copyright.	Figure 7B of Kanzler et al., 2000 [PMID:10662648] . Copyright: This image is from Development and is displayed with permission of The Company of Biologists Ltd. who owns the copyright.

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Notes:

Abbreviations used: ne, neural ectoderm; se, surface ectoderm. The section plane in C is indicated in B.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

3D mapping

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Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

surface ectoderm

detected

regional

Expression is where the surface ectoderm contacts the neuroepithelium.

neural ectoderm

detected

regional

Expression is along the entire lateral (prospective dorsal) margin of the neural folds

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:11030
Entity Detected:	Bmp2, bone morphogenetic protein 2 ( MGI:88177)
Notes:	The Bmp2 probe used in this study by Kanzler et al., 2000 [PMID:10662648] was originally described in Lyons et al., 1989 [PMID:2481605] as "a 1124-bp EcoRI fragment from the murine BMP-2a cDNA". Unable to determine an EcoRI fragment of this length - exact probe end points undefined.
Chemistry:	RNA
Strand:	antisense
Label:	digoxigenin

Specimen

Organism:	mouse
Age:	6-8 Somite no.
Theiler Stage:	TS12
Mutations:	none (wild-type)
Preparation:	wholemount plus section of wholemount

Procedures

Fixation:

4% paraformaldehyde

General Information

Authors:	Kanzler et al., 2000 [PMID:10662648] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ PMID:10662648] Kanzler B, Foreman RK, Labosky PA, Mallo M 2000 BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest. Development (127):1095-104
	[ doi:10.1101/gad.3.11.1657] [ PMID:2481605] Lyons KM, Pelton RW, Hogan BL 1989 Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic developm Genes Dev (3):1657-68
Links:	MGI:1352813 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source