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EMAGE:1050

Bmp6 bone morphogenetic protein 6 ( MGI:88182)
TS16 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:1050
Figure 5K of Furuta et al., 1997 [PMID:9187146] . Copyright: This image is from Development and is displayed with permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: two stars
Find spatially similar expression patterns: Find spatially similar patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:1050EMAGE:1050Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mapping3D context movie

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
1050_voxel_strong_3D_1.wlz
1050_voxel_moderate_3D_1.wlz
1050_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:1050_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
future brain
detected detected
Expression pattern is similar to Hfh4 [Foxj1].
Annotation Validation: Submitter + EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:9001
Entity Detected:Bmp6, bone morphogenetic protein 6 ( MGI:88182)
Sequence:sense strand is shown

>MGI:9001
GACGGCCCGCGAGGAGCCCCCTCCAGGGCGGCTGAAGTCCGCTCCACTCTTCATGCTGGATCTCTACAAC
GCCCTGTCCAATGACGACGAAGAGGATGGGGCATCGGAGGGTGTGGGGCAAGAGCCTGGGTCCCACGGAG
GGGCCAGCTCGTCCCAGCTCAGGCAGCCGTCTCCCGGCGCTGCACACTCCTTGAACCGCAAGAGTCTCCT
GGCCCCGGGACCCGGTGGCGGTGCGTCCCCACTGACTAGCGCGCAGGACAGCGCTTTCCTCAACGACGCG
GACATGGTCATGAGCTTTGTGAACCTGGTGGAGTACGACAAGGAGTTCTCCCCACATCAACGACACCACA
AAGAGTTCAAGTTCAACCTATCCCAGATTCCTGAGGGTGAGGCGGTGACGGCTGCTGAGTTCCGCGTCTA
CAAGGACTGTGTGGTGGGGAGTTTTAAAAACCAAACCTTTCTTATCAGCATTTACCAAGTCTTGCAGGAG
CATCAGCACAGAGACTCTGACCTATTTTTGTTGGACACCCGGGTGGTGTGGGCCTCAGAAGAAGGTTGGC
TGGAATTTGACATCACAGCAACTAGCAATCTGTGGGTGGTGACACCGCAGCACAACATGGGGCTCCAGCT
GAGTGTGGTGACTCGGGATGGACTCCACGTCAACCCCCGTGCGGCGGGCCTGGTGGGCAGAGACGGCCCT
TACGACAAGCAGCCCTTCATGGTGGCCTTCTTCAAGGTGAGCGAGGTCCACGTGCGCACCACCAGGTCAG
CCTCCAGTCGGCGGCGGCAGCAGAGTCGCAACCGGTCCACCCAGTCGCAGGACGTGTCCCGGGGCTCCGG
TTCTTCAGACTACAACGGCAGTGAGTTAAAAACAGCTTGCAAGAAGCATGAGCT
nt 564 - nt 1457 of NM_007556.1
Notes:The Bmp6 (Vgr1) probe used in this study by Furuta et al., 1997 [PMID:12930780] is indicated as "a 900 bp fragment of Bmp6 (Jones et al., 1991 [PMID:1893873] )". Jones et al. in turn refer to Lyons et al., 1989 [PMID:2481605] who describe "an 893-bp SacI-EcoRI fragment from the 5' region of the Vgr-1 cDNA (Lyons et al., 1989 [PMID:2734307] )." As restriction analysis of Bmp6/Vgr1 clones in the public databases (eg NM_007556.1) finds an internal SacI cut site, but no 5' EcoRI site, this 5' EcoRI site is presumably linker derived. The fragment shown above extends 5' from the SacI site at nt1457 for 893nt.
Chemistry:RNA
Strand:antisense
Label:S35
Specimen
Organism:mouse
Strain:ICR
Age:10.5 dpc
Theiler Stage:TS16
Mutations:none (wild-type)
Preparation:section
Procedures
Staining procedure:autoradiography
General Information
Authors:Furuta et al., 1997 [PMID:9187146] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:9187146] Furuta Y, Piston DW, Hogan BL 1997 Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development (124):2203-12
 [ PMID:1893873] Jones CM, Lyons KM, Hogan BL 1991 Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development (111):531-42
 [ doi:10.1101/gad.3.11.1657] [ PMID:2481605] Lyons KM, Pelton RW, Hogan BL 1989 Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic developm Genes Dev (3):1657-68
 [ doi:10.1073/pnas.86.12.4554] [ PMID:2734307] Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R 1989 Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A (86):4554-8
Links:MGI:1276853 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI