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EMAGE:1253

Mtap2 microtubule-associated protein 2 ( MGI:97175)
TS20 (12.5 dpc)
immunohistochemistry

Data Images
EMAGE:1253 EMAGE:1253 EMAGE:1253
Fig 1Ca, Handler et al, 2000 [PMID:10821758] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd who owns the copyright. Fig 1 Part 2, Handler et al, 2000 [PMID:10821758] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd who owns the copyright. Fig 1Ce, Handler et al, 2000 [PMID:10821758] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd who owns the copyright.

Expression pattern clarity: two stars
Find spatially similar expression patterns: Find spatially similar patterns
Notes:
The regions shown in images 1 and 2 are indicated by the red boxes marked "a-d" and "e,f" respectively in image 3. Image annotations: vz - ventricular zone, lv - lateral ventricle, v3 - third ventricle.
Expression Pattern Description
Spatial Annotation:
EMAGE:1253EMAGE:1253Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mapping3D context movie

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
1253_voxel_strong_3D_1.wlz
1253_voxel_moderate_3D_1.wlz
1253_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:1253_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
telencephalon
detected detected
regionalExpression is in post-mitotic neurons (Fig1Ca)
diencephalon
detected detected
regionalExpression is in post-mitotic neurons (Fig1Ce)
Annotation Validation: EMAGE Editor
Detection Reagent
Type:antibody
Identifier:MGI:1859881
Entity Detected:Mtap2, microtubule-associated protein 2 ( MGI:97175)
Notes:The anti-MTAP2 antibody used in this study by Handler et al, 2000 [PMID:10821758] is described as "anti- microtubule- associated protein 2 (MAP2) monoclonal antibody (1:1000, kindly provided by Dr Ken Kosik)".
Antibody Type:monoclonal
Raised In:mouse
Specimen
Organism:mouse
Strain:(129S2/SvPas x C57BL/6) or (129S4/SvJae x C57BL/6)
Age:12.5 dpc
Theiler Stage:TS20
Mutations:Psen1tm1Shn/Psen1+
Preparation:section
Procedures
Fixation:4% paraformaldehyde
Embedding:cryosection
Secondary Antibody:goat anti-mouse
Labelled with:rhodamine
Visualisation method:fluorescence
General Information
Authors:Handler et al, 2000 [PMID:10821758] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:10821758] Handler M, Yang X, Shen J 2000 Presenilin-1 regulates neuronal differentiation during neurogenesis. Development (127):2593-606
Links:MGI:1859882 same experiment
 MGI:1857974 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI