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EMAGE:1268

Gsx2 GS homeobox 2 ( MGI:95843)
TS20 (12.5 dpc)
immunohistochemistry

Data Images
EMAGE:1268
Figure 1C of Toresson et al., 2000 [PMID:11003836] . Copyright: This image is from Development and is displayed with permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Notes:
Abbreviations used: LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence. Arrow delineates boundary between the GSH2 and PAX6 expression domains.
Expression Pattern Description
Spatial Annotation:
EMAGE:1268EMAGE:1268Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mapping3D context movie

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
1268_voxel_strong_3D_1.wlz
1268_voxel_moderate_3D_1.wlz
1268_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:1268_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
telencephalon
detected detected
regionalExpression in progenitors of both the medial ganglionic eminence (MGE) and lateral ganglionic eminence (LGE) VZ; graded along the dorsal-ventral axis; highest levels in progenitor cells close to the boundary with PAX6.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:antibody
Identifier:MGI:2150169
Entity Detected:Gsx2, GS homeobox 2 ( MGI:95843)
Antigen:sense strand is shown

>MGI:2150169
ANEDKEISPL
aa 296 - aa 305 of P31316
Notes:The anti-Gsh2 antibody used in this study by Toresson et al., 2000 [PMID:11003836] was "was raised in rabbits against the C-terminal peptide, ANEDKEISPL (Hsieh-Li et al., 1995 [PMID:7619729] )". See also Figure 1 in Hsieh-Li et al.
Antibody Type:polyclonal
Raised In:rabbit
Specimen
Organism:mouse
Age:12.5 dpc
Theiler Stage:TS20
Mutations:none (wild-type)
Preparation:section
Procedures
Fixation:4% paraformaldehyde
Embedding:cryosection
General Information
Authors:Toresson et al., 2000 [PMID:11003836] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:11003836] Toresson H, Potter SS, Campbell K 2000 Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. Development (127):4361-71
 [ doi:10.1016/0925-4773(94)00334-J] [ PMID:7619729] Hsieh-Li HM, Witte DP, Szucsik JC, Weinstein M, Li H, Potter SS 1995 Gsh-2, a murine homeobox gene expressed in the developing brain. Mech Dev (50):177-86
Links:MGI:2150330 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI