Quicksearch Help

(Click the icon to keep this page displayed.)

EMAGE:250

Tlx2 T-cell leukemia, homeobox 2 ( MGI:1350935)
TS10 (7.0 dpc)
in situ hybridisation

Data Images
EMAGE:250 EMAGE:250
Fig 1B Tang et al, 1998 [PMID:9550720] . Copyright: This image is from Development and is displayed with the permission fo the Company of Biologists Ltd. who owns the copyright. Fig 1C Tang et al, 1998 [PMID:9550720] . Copyright: This image is from Development and is displayed with the permission fo the Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
In B: Arrowhead points to the proximal lateral region. Arrow points to primitive streak. Image C has not been spatially mapped but is included here to show a section through a roughly equivalent stage embryo to that shown in B. In C, the authors state expression is detected in: primitive streak ectoderm (e), and anterior proximal and extraembryonic ectoderm (arrowheads) and that signal is not detected in mesoderm (m) and endoderm (e).
Expression Pattern Description
Spatial Annotation:
EMAGE:250Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
250_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:250_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
embryo
detected detected
regionalTlx-2 was observed in the proximal lateral region
primitive streak
detected detected
regionalTlx-2 was observed in the ectoderm of the primitive streak, and the ectoderm of anterior proximal and extraembryonic regions
embryo mesoderm
not detected not detected
embryo endoderm
not detected not detected
embryo ectoderm
detected detected
regionalTlx-2 was observed in the ectoderm of the primitive streak, and the ectoderm of anterior proximal and extraembryonic regions
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1276508
Entity Detected:Tlx2, T-cell leukemia, homeobox 2 ( MGI:1350935)
Notes:Two Tlx2 probes were used in this study by Tang et al, 1998 [PMID:9550720] , both of which are of unspecified sequence and both of which "yielded the same expression pattern, whereas the corresponding sense probes did not produce specific signals".
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:7.0 dpc
Theiler Stage:TS10
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Tang et al, 1998 [PMID:9550720] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:9550720] Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M 1998 The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development (125):1877-87
Links:MGI:1316852 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI