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EMAGE:251

Tlx2 T-cell leukemia, homeobox 2 ( MGI:1350935)
TS11 (7.5 dpc)
in situ hybridisation

Data Images
EMAGE:251 EMAGE:251 EMAGE:251
Fig 1D Tang et al, 1998 [PMID:9550720] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd. who owns the copyright. Fig 1E Tang et al, 1998 [PMID:9550720] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd. who owns the copyright. Fig 1F Tang et al, 1998 [PMID:9550720] . Copyright: This image is from Development and is displayed with the permission of the Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
The arrow and line in D show the planes of the sections in E and F respectively. The arrow also points to the posterior primitive streak. Arrowheads point to the lateral neuroepithelium. In E and F: arrows point to posterior primitive streak and lateral neuroepithelium respectively. Arrowheads point to the head folds. E and F have not been spatially mapped due their size.
Expression Pattern Description
Spatial Annotation:
EMAGE:251Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
251_wholemount_strong_3D_1.wlz
251_wholemount_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:251_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
embryo
detected detected
regionalAt this stage, Tlx-2 was seen only in the extreme posterior end of the primitive streak and in two symmetrical stripes that extended laterally on either side of the streak.
primitive streak
detected detected
regionalAt this stage, Tlx-2 was seen only in the extreme posterior end of the primitive streak and in two symmetrical stripes that extended laterally on either side of the streak. Tlx-2 expression was localized in both the ectoderm and mesoderm at the posterior end of the primitive streak. In regions immediately anterior to this, expression in the stripes occurred in the ectoderm and was excluded from the midline and the mesoderm
node
not detected not detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1276508
Entity Detected:Tlx2, T-cell leukemia, homeobox 2 ( MGI:1350935)
Notes:Two Tlx2 probes were used in this study by Tang et al, 1998 [PMID:9550720] , both of which are of unspecified sequence and both of which "yielded the same expression pattern, whereas the corresponding sense probes did not produce specific signals".
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Strain:CD1
Age:7.5 dpc
Theiler Stage:TS11
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Tang et al, 1998 [PMID:9550720] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:9550720] Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M 1998 The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development (125):1877-87
Links:MGI:1316852 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI