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EMAGE:295

Wnt7a wingless-related MMTV integration site 7A ( MGI:98961)
TS22 (14 dpc)
in situ hybridisation

Data Images
EMAGE:295 EMAGE:295 EMAGE:295
Figure 6A of Dabdoub et al., 2003 [PMID:12702652] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright. Figure 6B of Dabdoub et al., 2003 [PMID:12702652] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright. Figure 6C of Dabdoub et al., 2003 [PMID:12702652] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: no stars
Notes:
Image annotations: (A) A band of Wnt7a expression is present in the basal region (base) of the cochlea (arrow). In the apical turn (apex) of the cochlea, Wnt7a expression spans most of the width of the floor of the cochlear duct. (B) Cross-section through the apical turn of the cochlea at E14. For all cross-sections, inner is towards the left, outer is towards the right. There is broad expression of Wnt7a throughout the epithelium. However, there is a distinct boundary of Wnt7a expression (arrow) that correlates with the spiral vessel (asterisk), an embryonic marker for the location of the developing organ of Corti. (C) Cross-section through the basal region of the cochlear duct at E14. Wnt7a expression persists in a band of cells that extends from the boundary at the spiral vessel (arrow) towards the inner-side of the duct (arrowhead). In addition, Wnt7a is still expressed in some cells located at the inner edge of the duct.
Expression Pattern Description
Text Annotation:
StructureLevelPatternNotes
cochlea
detected detected
regionalFig 6A - Expression is present in the basal region of the cochlea.
cochlear duct
detected detected
regionalFig 6A - The expression spans most of the width of the floor of the duct in the apical turn of the cochlea. Fig 6C - Expression is present in a band of cells that extends from the boundary of the spiral vessel towards the inner side of the duct, as well as in some cells located at the inner edge of the duct.
cochlear duct epithelium
detected detected
regionalFig6B - There is broad expression in the inner half of the epithelium. However, there is a distinct boundary of expression that correlates with the spiral vessel, an embryonic marker for the location of the developing organ of Corti.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:2655269
Entity Detected:Wnt7a, wingless-related MMTV integration site 7A ( MGI:98961)
Notes:The Wnt7a probe used in this study by Dabdoub et al., 2003 [PMID:12702652] is of undefined sequence.
Chemistry:RNA
Strand:antisense
Specimen
Organism:mouse
Age:14 dpc
Theiler Stage:TS22
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Dabdoub et al., 2003 [PMID:12702652] . Indexed by GXD.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1242/dev.00448] [ PMID:12702652] Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW 2003 Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (130):2375-84
Links:MGI:2655282 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI