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EMAGE:3299

Emx2 empty spiracles homolog 2 (Drosophila) ( MGI:95388)
TS20 (12.5 dpc)
in situ hybridisation

Data Images
EMAGE:3299
Figure 4E of Ligon et al., 2003 [PMID:12668639] . Copyright: This image is from Ligon et al., Development 130:2275-87 (2003), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Notes:
Note: Coronal section of E12.5 telencephalon. Abbreviations: cpp, choroid plexus primordium; hem, cortical hem. Bracket indicates the cortical hem.
Expression Pattern Description
Spatial Annotation:
EMAGE:3299EMAGE:3299Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mappingspatial mapping

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
3299_voxel_strong_3D_1.wlz
3299_voxel_moderate_3D_1.wlz
3299_voxel_weak_3D_1.wlz
3299_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:3299_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
cerebral cortex ventricular layer
detected detected
gradedExpression was stronger in dorsomedial regions than in dorsolateral regions.
cerebral cortex
detected detected
regionalExpression was detected in the cortical hem.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:9330
Entity Detected:Emx2, empty spiracles homolog 2 (Drosophila) ( MGI:95388)
Notes:The probe used in this study by Ligon et al., 2003 [PMID:12668639] is indicated as that originally described in Simeone et al., 1992 [PMID:1352754] , i.e. a "650 nucleotide AIul-EcoRl fragment" that covers part of the C-terminal of Emx2 cDNA and 3' UTR. The sequence could not be deduced from the available information.
Chemistry:RNA
Strand:antisense
Specimen
Organism:mouse
Age:12.5 dpc
Theiler Stage:TS20
Mutations:none (wild-type)
Preparation:section
Procedures
Fixation:4% paraformaldehyde
General Information
Authors:Ligon KL; Echelard Y; Assimacopoulos S; Danielian PS; Kaing S; Grove EA; McMahon AP; Rowitch DH, 2003 [PMID:12668639] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1242/dev.00421] [ PMID:12668639] Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH 2003 Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development (130):2275-87
 [ PMID:1352754] Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M, Boncinelli E 1992 Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J (11):2541-50
Links:MGI:2673720 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI