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EMAGE:3306

Evx1 even skipped homeotic gene 1 homolog ( MGI:95461)
TS17 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:3306 EMAGE:3306 EMAGE:3306 EMAGE:3306
Fig 1B (forelimb) Niswander & Martin, 1993 [PMID:7506139] .Copyright: This image is from Niswander et al. Development 119:287-294 (1993), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright. Fig 1A (forelimb) Niswander & Martin, 1993 [PMID:7506139] . Copyright: This image is from Niswander et al. Development 119:287-294 (1993), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright. Fig 1A (hindlimb) Niswander & Martin, 1993 [PMID:7506139] . Copyright: This image is from Niswander et al. Development 119:287-294 (1993), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright. Fig 1B (hindlimb) Niswander & Martin, 1993 [PMID:7506139] .Copyright: This image is from Niswander et al. Development 119:287-294 (1993), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Notes:
Note: FL, forelimb; HL, hindlimb; arrowheads point the the apical ectodermal ridge.
Expression Pattern Description
Spatial Annotation:
EMAGE:3306EMAGE:3306EMAGE:3306Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mapping3D mappingspatial mapping

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
3306_voxel_notDetected_3D_1.wlz
3306_voxel_strong_3D_1.wlz
3306_voxel_notDetected_3D_2.wlz
(what is wlz format?)
Download all expression domains: EMAGE:3306_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
forelimb bud mesenchyme
detected detected
regionalEvx1 RNA is detected at E10.5 in the distal mesenchyme of the forelimb.
hindlimb bud
not detected not detected
homogeneous
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1316840
Entity Detected:Evx1, even skipped homeotic gene 1 homolog ( MGI:95461)
Notes:The Evx1 probe used in this study by Niswander & Martin, 1993 [PMID:7506139] is described as "a 700 bp fragment from the 3' end of the gene (Dush and Martin, 1992 [PMID:1349539] )". Editor's note: Dush & Martin, 1992 mention a 700bp Evx1 probe fragment from the 3' end of the gene (it is labelled as Probe3 in Fig 1 therein), however information on the start and end points are not given. Probe sequence is unknown.
Chemistry:RNA
Strand:antisense
Label:S35
Specimen
Organism:mouse
Strain:Swiss Webster
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:section
Procedures
Fixation:4% paraformaldehyde
Embedding:paraffin
Staining procedure:autoradiography
General Information
Authors:Niswander L & Martin GR, 1993 [PMID:7506139] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:7506139] Niswander L, Martin GR 1993 FGF-4 regulates expression of Evx-1 in the developing mouse limb. Development (119):287-94
 [ doi:10.1016/0012-1606(92)90232-6] [ PMID:1349539] Dush MK, Martin GR 1992 Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak. Dev Biol (151):273-87
Links:MGI:1930582 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI