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EMAGE:3510

Gsc goosecoid homeobox ( MGI:95841)
TS11 (HF Downs & Davies)
in situ hybridisation

Data Images
EMAGE:3510 EMAGE:3510 EMAGE:3510
Fig3B.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(97)00204-9] Mech Dev 1998 Mar;72(1-2):15-25, Belo JA; Leyns L; Yamada G; De Robertis EM, The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Copyright 1998. Fig3A.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(97)00204-9] Mech Dev 1998 Mar;72(1-2):15-25, Belo JA; Leyns L; Yamada G; De Robertis EM, The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Copyright 1998. Fig3C.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(97)00204-9] Mech Dev 1998 Mar;72(1-2):15-25, Belo JA; Leyns L; Yamada G; De Robertis EM, The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Copyright 1998.

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Notes:
Note: Arrowheads in A indicate where the sections in B and C were taken. Arrowheads in B indicate anterior mesendoderm. Arrowheads in C indicate notochordal plate. Abbreviations: NP, notochordal plate, PP, prechordal plate.
Expression Pattern Description
Spatial Annotation:
EMAGE:3510EMAGE:3510EMAGE:3510Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mapping3D mappingspatial mapping

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
3510_voxel_notDetected_3D_1.wlz
3510_voxel_strong_3D_1.wlz
3510_voxel_moderate_3D_1.wlz
3510_voxel_notDetected_3D_2.wlz
3510_voxel_strong_3D_2.wlz
(what is wlz format?)
Download all expression domains: EMAGE:3510_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
embryo
detected detected
regionalExpression is in the anterior midline.
embryo endoderm
detected detected
regionalExpression is in the anterior mesendoderm that constitutes the prechordal plate.
embryo mesoderm
detected detected
regionalExpression is in the anterior mesendoderm that constitutes the prechordal plate.
neural ectoderm
detected detected
notochordal plate
not detected not detected
homogeneous
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1196638
Entity Detected:Gsc, goosecoid homeobox ( MGI:95841)
Notes:The Gsc probe used in this study by Belo et al., 1998 [PMID:9533949] is indicated as that originally described in Belo et al., 1997 [PMID:9431803] i.e. a "full-length cDNA". Editors Note: The exact start and end points of this probe are not defined.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Strain:(C57BL/6J x SJL/J)F1
Age:HF Downs & Davies
Theiler Stage:TS11
Mutations:none (wild-type)
Preparation:sectioned wholemount
Procedures
Fixation:4% paraformaldehyde
Embedding:paraffin
Staining procedure:alkaline phosphatase + unspecified
General Information
Authors:Belo JA; Leyns L; Yamada G; De Robertis EM, 1998 [PMID:9533949] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/S0925-4773(97)00204-9] [ PMID:9533949] Belo JA, Leyns L, Yamada G, De Robertis EM 1998 The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Mech Dev (72):15-25
 [ doi:10.1016/S0925-4773(97)00125-1] [ PMID:9431803] Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M, De Robertis EM 1997 Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev (68):45-57
Links:MGI:2429938 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI