EMAGE mouse gene expression spatial database

EMAGE:3541

Prox1 prospero-related homeobox 1 ( MGI:97772)
TS12 (6-8 Somite no.)
in situ reporter

Data Images


Fig1C.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(02)00240-X] Mech Dev 118: 147, Burke Z; Oliver G, Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Copyright 2002.

Expression pattern clarity:
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Notes:

Note: Arrow indicates the node. White arrowhead indicates the anterior cephalic region.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

wholemount mapping

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Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

primitive streak

detected

regional

Expression is present in the regressing node.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ reporter
Entity Detected:	Prox1, prospero-related homeobox 1 ( MGI:97772)
Notes:	Prox1 expression was detected in this study by Burke & Oliver, 2002 [PMID:12351178] thus: "We have previously reported the inactivation of the mouse Prox1 gene by the in-frame insertion of the lacZ gene. The lacZ gene, which encodes beta-Gal, was inserted at amino acid 224 of Prox1 (Wigle et al., 1999 [PMID:10080188] ). The resulting lacZ activity allowed us to easily detect cells that normally express Prox1 throughout development."
Labelled with:	LacZ

Specimen

Procedures

Fixation:

4% paraformaldehyde

General Information

Authors:	Burke Z & Oliver G, 2002 [PMID:12351178] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1016/S0925-4773(02)00240-X] [ PMID:12351178] Burke Z, Oliver G 2002 Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech Dev (118):147-55
	[ doi:10.1038/6844] [ PMID:10080188] Wigle JT, Chowdhury K, Gruss P, Oliver G 1999 Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet (21):318-22
Links:	MGI:3529572 same experiment
	MGI:2386336 allele description
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source