EMAGE mouse gene expression spatial database

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EMAGE:3871

Dkk1 dickkopf homolog 1 (Xenopus laevis) ( MGI:1329040)
TS17 (9.75 dpc)
in situ hybridisation

Data Images


Fig3A.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(99)00138-0] Mech Dev 87: 45-56, Monaghan AP; Kioschis P; Wu W; Zuniga A; Bock D; Poustka A; Delius H; Niehrs C, Dickkopf genes are co-ordinately expressed in mesodermal lineages. Copyright 1999

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Image annotation: arrow = region of elevated expression.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

3871_wholemount_strong_3D_1.wlz

3871_wholemount_moderate_3D_1.wlz

3871_wholemount_notDetected_3D_1.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:3871_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

limb

detected

regional

Expressed in mesenchyme: Expression is present in superficial anterior and posterior mesenchyme cell populations just under the surface ectoderm. Expression is higher proximally in cells surrounding the junction between the limb bud and body wall.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:1329444
Entity Detected:	Dkk1, dickkopf homolog 1 (Xenopus laevis) ( MGI:1329040)
Sequence:	sense strand is shown >MGI:1329444 GACCCACGCGTCCGTGCCTGTTTGCGTCCTTCGGAGATGATGGTTGTGTGTGCACCGGCAGCTGTCCGGT TCTTGGCCGTGTTTACAATGATGGCTCTCTGCAGCCTCCCTCTGCTAGGAGCCAGTGCCACCTTGAACTC AGTTCTCATCAATTCCAACGCGATCAAGAACCTGCCCCCACCGCTGGGTGGTGCTGGGGGGCAGCCGGGC TCTGCTGTCAGTGTGGCGCCGGGAGTTCTCTATGAGGGCGGGAACAAGTACCAGACTCTTGACAACTACC AGCCCTACCCTTGCGCTGAAGATGAGGAGTGCGGCTCTGACGAGTACTGCTCCAGCCCCAGCCGCGGGGC AGCCGGCGTCGGAGGTGTACAGATCTGTCTGGCTTGCCGAAAGCGCAGGAAGCGCTGCATGACGCACGCT ATGTGCTGCCCCGGGAACTACTGCAAAAATGGAATATGCATGCCCTCTGACCACAGCCATTTTCCTCGAG GGGAAATTGAGGAAAGCATCATTGAAAACCTTGGTAATGACCACAACGCCGCCGCGGGGGATGGATATCC CAGAAGAACCACACTGACTTCAAAAATATATCACACCAAAGGACAAGAAGGCTCCGTCTGCCTCCGATCA TCAGACTGTGCCGCAGGGCTGTGTTGTGCAAGACACTTCTGGTCCAAGATCTGTAAACCTGTCCTTAAAG AAGGTCAGGTGTGCACCAAGCACAAACGGAAAGGCTCCCACGGGCTGGAGATATTCCAGCGCTGTTACTG CGGGGAAGGCCTGGCTTGCAGGATACAGAAAGATCACCATCAAGCCAGCAATTCTTCTAGGCTCCACACC TGCCAGAGACACTAAACCGACAGTCTAAATATGATGGACTCTTTTTATCTAATATATGCTACGAAAATCC TTTATGATTTGTCAGCTCAATCCCAAGGATGTAGGAATCTTCAGTGTGTAATTAAGCATTCCGACAATAC TTTCCAAAAGCTCTGGAGTGTAAGGACTTTGTTTCTTGATGGAACTCCCCTGTGATTGCAGTAAATTACT GTGTTGTAAATCCTCAGTGTGGCACTTACCTGTAAATGCAGCAAAACTTTTAATTATTTTTCTAGAGGTG TGGTACATTGCCTTGTTTCTCTTGCATGTAAATTTTTTTTGTACACGGTTGATTGTCTTGACTCATAAAT ATTCTATATTGGAGTAGAAAAAAAAAAAAAAAAAAA
	nt 1 - nt 1226 of AF030433.1
Notes:	The Dkk1 probe used in this study by Monaghan et al, 1999 [PMID:10495270] is described as being transcribed from "full length dkk-1 (Glinka et al., 1998 [PMID:9450748] )". Glinka et al generated an in situ hybridisation probe from a clone that was isolated from a mouse embryonic day 9 cDNA library by the RZPD (clone MPMGc559P2481Q3). AF030433.1 is the accompanying GenBank entry for the insert sequence of this clone.
Chemistry:	RNA
Strand:	antisense

Specimen

Organism:	mouse
Strain:	NMRI
Age:	9.75 dpc
Theiler Stage:	TS17
Mutations:	none (wild-type)
Preparation:	wholemount

Procedures

General Information

Authors:	Monaghan AP; Kioschis P; Wu W; Zuniga A; Bock D; Poustka A; Delius H; Niehrs C, 1999. [PMID:10495270] . Indexed by GXD, Spatially mapped by EMAGE
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1016/S0925-4773(99)00138-0] [ PMID:10495270] Monaghan AP, Kioschis P, Wu W, Zuniga A, Bock D, Poustka A, Delius H, Niehrs C 1999 Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev (87):45-56
	[ doi:10.1038/34848] [ PMID:9450748] Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C 1998 Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (391):357-62
Links:	MGI:3603169 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source