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EMAGE:4137

Dll4 delta-like 4 (Drosophila) ( MGI:1859388)
TS16 (10.5 dpc)
in situ reporter

Data Images
EMAGE:4137
Figure 1A. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2005.04.004] Gene Expr Patterns 5: 750-5, Benedito R; Duarte A, Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Copyright 2005.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Note: dorsal aortae (ao), vitelline artery (va) and internal carotid artery (ica), neural tube (nt) and hindbrain (h).
Expression Pattern Description
Spatial Annotation:
EMAGE:4137Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4137_wholemount_strong_3D_1.wlz
4137_wholemount_moderate_3D_1.wlz
4137_wholemount_weak_3D_1.wlz
4137_wholemount_possible_3D_1.wlz
4137_wholemount_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4137_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
arterial system
detected detected
dorsal aorta
detected detected
vitelline artery
detected detected
internal carotid artery
detected detected
future hindbrain
detected detected
neural tube
detected detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Dll4, delta-like 4 (Drosophila) ( MGI:1859388)
Notes:Dll4 expression was detected in this study by Benedito & Duarte, 2005 [PMID:15923152] using "Dll4+/- mice containing a targeted Dll4 allele in which an in-frame insertion of the beta-galactosidase (lacZ) reporter gene replaced the first three coding exons (Duarte et al., 2004)". Duarte et al. describe the mutant allele as: "a 2.0-kilobase (kb) DNA fragment encompassing the start codon and the first three exons of the Dll4-coding sequence was deleted and substituted by a lacZ and PGK-neo cassette, flanked by 1.5-kb 5'and 5-kb 3' homologous regions" (see Figure 1A therein).
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129S1/Sv * 129X1/SvJ * ICR
Age:10.5 dpc
Theiler Stage:TS16
Mutations:Dll4tm1Jrt/Dll4+
Preparation:wholemount
Procedures
Fixation:0.2% glutaraldehyde
General Information
Authors:Benedito R & Duarte A, 2005 [PMID:15923152] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.modgep.2005.04.004] [ PMID:15923152] Benedito R, Duarte A 2005 Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns (5):750-5
 [ doi:10.1101/gad.1239004] [ PMID:15466159] Duarte A, Hirashima M, Benedito R, Trindade A, Diniz P, Bekman E, Costa L, Henrique D, Rossant J 2004 Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (18):2474-8
Links:MGI:3587944 same experiment
 MGI:3056400 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI