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EMAGE:449

Nkx2-1 NK2 homeobox 1 ( MGI:108067)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:449
Figure 6D of Theil et al., 1999 [PMID:10409502] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: vd - ventral diencephalon; vt - ventral telencephalon.
Expression Pattern Description
Spatial Annotation:
EMAGE:449Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
449_wholemount_strong_3D_1.wlz
449_wholemount_possible_3D_1.wlz
449_wholemount_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:449_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
diencephalon
detected detected
regionalExpression was restricted to the ventral diencephalon.
telencephalon
detected detected
regionalExpression was restricted to the ventral telencephalon.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1340511
Entity Detected:Nkx2-1, NK2 homeobox 1 ( MGI:108067)
Sequence:sense strand is shown

>MGI:1340511
ACGAATTCTTTAACCAGAGAAGGACAAAGAACAAATTTGGGGGTCTTTCTGGTAGTTCAAATGGGTTCTC
AAGCTTAGGCATGGCACAATTTTGGGGCCTGCTCTATGCTTCCACGGCCCTGAACTCTGAAGCCGGAAAA
CTTCCCTGTGGATGCACTCTGCCAGCAAAGAGAGCTTGCTTGTAAATACCAGGATTTTTCGTTTGTTTGT
TTCAGAAGGGAGGACAGAAACTGGAGAGAGGAAAGATTCTTCAGCATAACCCACTTGTCCCTGACACAAA
GGAAGTGTCCCCTCCCAGGTGCCCTCTGGCCCTATAGGTTCAGTCCAGGCTGGCCTTTCAGAAAATTGTT
TTAGGTTTGATGTGAACTTGTAGCTGTAAAATGCTGTCAAAAGTTGGACTAAATGCCTAGTTTTTAGTAA
CCTGTACATTATGTTGTAAAAAGAACTCCAGTCCCAGTCCCTGGCCCCTCACTTTTTAAAAGGGCATCAT
CGACAAGCCTGTGTATATTACTCCACGGTTTGGTATTTGCAGCACCAGTTGCCCCCTCCCTTTTTTCTGT
TGTAACTTATGTAGATATTTGGCTTAAATATAGTTCCTAAGAAGCTTCTAATAAATTATACGAATT
nt 1694 - nt 2319 of X53858.1
Notes:The Titf1(Nkx2.1, TTF-1) probe used in this study by Theil et al., 1999 [PMID:10409502] is indicated as that described by Lazzaro et al., 1999 [PMID:1811929] ie. "a 625 bp fragment derived from the 3' non-translated region of the (rat) TTF-1 cDNA (bp 1694-2319, Guazzi et al. 1990 [PMID:1976511] ) ".
Chemistry:RNA
Strand:antisense
Specimen
Organism:mouse
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Theil et al., 1999 [PMID:10409502] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:10409502] Theil T, Alvarez-Bolado G, Walter A, Ruther U 1999 Gli3 is required for Emx gene expression during dorsal telencephalon development. Development (126):3561-71
 [ PMID:1976511] Guazzi S, Price M, De Felice M, Damante G, Mattei MG, Di Lauro R 1990 Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J (9):3631-9
 [ PMID:1811929] Lazzaro D, Price M, de Felice M, Di Lauro R 1991 The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development (113):1093-104
Links:MGI:1340542 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI