Quicksearch Help

(Click the icon to keep this page displayed.)

EMAGE:4582

Ctnna2 catenin (cadherin associated protein), alpha 2 ( MGI:88275)
TS17 (10.5 dpc)
immunohistochemistry

Data Images
EMAGE:4582
Figure 4A. Copyright: This image is from Shimamura et al., Development 121: 3923-3933 (1995) [PMID:8575293] and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Note: A, lateral view of 10.5 dpc brain stained for alpha-N-catenin protein (brown) and Nkx2.2 mRNA (purple). Selected transverse sections of a similar preparation are shown in B -E where section planes are indicated in A. ac, anlage of anterior commissure; cf, commissural fibers; dvdt, dorsoventral diencephalic tract; me, mesencephalon; mlf, medial longitudinal fasciculus; nV, exit point of the trigeminal nerve; os, optic stalk; poc, postoptic commissure; rh, rhombencephalon; sot, supraoptic tract; t, telencephalic vesicle; tmes, mesencephalic trigeminal tract; tpoc, tract of postopic commissure. Scale bar: 200 microns. See EMAGE:3282 for section images B,C,D.
Expression Pattern Description
Spatial Annotation:
EMAGE:4582Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4582_wholemount_moderate.wlz
4582_wholemount_weak.wlz
4582_wholemount_possible.wlz
4582_wholemount_notDetected.wlz
4582_wholemount_strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4582_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
brain
detected detected
regionalStaining is in developing neurons and axons.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:antibody
Identifier:MGI:1934640
Entity Detected:Ctnna2, catenin (cadherin associated protein), alpha 2 ( MGI:88275)
Notes:The anti-CTNNA2 (alpha-N-catenin) antibody used in this study by Shimamura et al., 1995 [PMID:8575293] is indicated as that used by Shimamura et al, 1994 [PMID:7925023] i.e. "Rat monoclonal antibody NCAT-2 was used for staining for alphaN-catenin (Hirano et al., 1992 [PMID:1638632] )".
Antibody Type:monoclonal
Raised In:rat
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
General Information
Authors:Shimamura K; Hartigan DJ; Martinez S; Puelles L; Rubenstein JL, 1995 [PMID:8575293] . Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:8575293] Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL 1995 Longitudinal organization of the anterior neural plate and neural tube. Development (121):3923-33
 [ PMID:7925023] Shimamura K, Hirano S, McMahon AP, Takeichi M 1994 Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development (120):2225-34
 [ doi:10.1016/0092-8674(92)90103-J] [ PMID:1638632] Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M 1992 Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell (70):293-301
Links:MGI:1934641 same experiment
 EMAGE:3282 same embryo
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI