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EMAGE:459

Tfap2a transcription factor AP-2, alpha ( MGI:104671)
TS15 (8.5 dpc)
in situ hybridisation

Data Images
EMAGE:459 EMAGE:459
Figure 7B of Solloway and Robertson, 1999 [PMID:10079236] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright. Figure 7C of Solloway and Robertson, 1999 [PMID:10079236] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: one star
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image C is a dorsal view of trunk ganglia near the forelimb bud seen in Image B. Image annotations: arrows indicate expression in the trunk ganglia; arrowheads indicate expression in the midbrain.
Expression Pattern Description
Spatial Annotation:
EMAGE:459Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
459_wholemount_strong_3D_1.wlz
459_wholemount_moderate_3D_1.wlz
459_wholemount_weak_3D_1.wlz
459_wholemount_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:459_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
1st branchial arch mandibular component mesenchyme derived from neural crest
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
future midbrain
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
limb
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
2nd branchial arch mesenchyme derived from neural crest
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
head mesenchyme derived from neural crest
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
3rd branchial arch mesenchyme derived from neural crest
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
spinal ganglion
detected detected
Arrows indicate expression in trunk ganglia and arrowheads indicate expression in midbrain.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:1333120
Entity Detected:Tfap2a, transcription factor AP-2, alpha ( MGI:104671)
Notes:The Tcfap2a (AP2) probe used in this study by Solloway and Robertson, 1999 [PMID:10079236] was referenced as that used by Zhang et al., 1996 [PMID:8622766] . Zhang do not describe an AP2 in situ hybridisation probe.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:8.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
Staining procedure:alkaline phosphatase + unspecified
General Information
Authors:Solloway & Robertson, 1999 [PMID:10079236] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:10079236] Solloway MJ, Robertson EJ 1999 Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development (126):1753-68
 [ doi:10.1038/381238a0] [ PMID:8622766] Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T 1996 Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (381):238-41
Links:MGI:1333139 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE