EMAGE mouse gene expression spatial database

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EMAGE:4601

Foxs1 forkhead box S1 ( MGI:95546)
TS19 (11.5 dpc)
in situ reporter

Data Images


Figure 4A. Copyright: This image is from Hjerling-Leffler J, Development 2005 Jun;132(11):2623-32 [PMID:15872002] and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.	Figure 4B. Copyright: This image is from Hjerling-Leffler J, Development 2005 Jun;132(11):2623-32 [PMID:15872002] and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Image annotations: Cerv, cervical; DRG, dorsal root ganglia; FGn, facial ganglion; JGn, jugular ganglion; Lumb, lumbar; Sacr, sacral; SGn, superior ganglion; TGn, trigeminal ganglion; Thor, thoracic. Scale bars: 1 mm in A

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

4601_wholemount_possible_3D_1.wlz

4601_wholemount_notDetected_3D_1.wlz

4601_wholemount_strong_3D_1.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:4601_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

spinal ganglion

strong

Strong expression was exclusively present in cranial and spinal sensory ganglia.

cranial ganglion

strong

Strong expression was exclusively present in cranial and spinal sensory ganglia.

facial vii ganglion

strong

glossopharyngeal ix ganglion

strong

trigeminal v ganglion

strong

inferior vagus x ganglion

strong

dorsal root ganglion

strong

cardiovascular system

weak

regional

Expressed in blood vessels.

sympathetic nervous system

not detected

homogeneous

Expression is not detected in sympathetic neurons

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ reporter
Entity Detected:	Foxs1, forkhead box S1 ( MGI:95546)
Notes:	Foxs1 (Fkh3) expression was detected in this study by Hjerling-Leffler et al., 2005 [PMID:15872002] using Fkh3-LacZ /+ mice that were generated as follows: "A 10 kb fragment from the Fkh3 locus was isolated and an nls-lacZ cassette also containing a neomycin-resistance gene, driven by the PGK promoter and polyA was put in frame 18 amino acids downstream of Fkh3 start codon, replacing a 600 bp part of the Fkh3 gene. Homologous recombined embryonic stem cell clones were injected into C57/Bl6 blastocysts to generate chimeric mice. After germline transmission, the mice were on a 129SVxC57/Bl6 background."
Labelled with:	LacZ

Specimen

Organism:	mouse
Strain:	involves: 129/Sv * C57BL/6
Age:	11.5 dpc
Theiler Stage:	TS19
Mutations:	Foxs1^tm1Pern/Foxs1⁺
Preparation:	wholemount

Procedures

Fixation:

Webster solution

General Information

Authors:	Hjerling-Leffler J; Marmigere F; Heglind M; Cederberg A; Koltzenburg M; Enerback S; Ernfors P, 2005 [PMID:15872002] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1242/dev.01852] [ PMID:15872002] Hjerling-Leffler J, Marmigere F, Heglind M, Cederberg A, Koltzenburg M, Enerback S, Ernfors P 2005 The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development (2005):2623-32
Links:	MGI:3579698 same experiment
	MGI:3579474 allele description
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source