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EMAGE:4638

Acvrl1 activin A receptor, type II-like 1 ( MGI:1338946)
TS15 (9.5 dpc)
in situ reporter

Data Images
EMAGE:4638
Fig1B. from [doi:10.1161/01.RES.0000095246.40391.3B] Circ Res 93: 682-689, Seki T; Yun J; Oh SP, Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Copyright 2003

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:4638Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4638_wholemount_moderate.wlz
4638_wholemount_weak.wlz
4638_wholemount_notDetected.wlz
4638_wholemount_strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4638_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
dorsal aorta
detected detected
arterial system
detected detected
regionalExpression was detected in intersomitic arteries.
cardiovascular system
detected detected
regionalExpression was detected in some capillaries.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Acvrl1, activin A receptor, type II-like 1 ( MGI:1338946)
Notes:Acvrl1 (Alk1) expression was detected in this in this study by Seki et al., 2003 [PMID:12970115] using embryos heterozygous for a mutation whereby exons 4 to 8 of Alk1 were replaced with an IRES-lacZ/PKGneomycin cassette. The transmembrane domain coded by exon 5 is thus eliminated. The embryos were stained with X-gal as described by Oh et al., 2000 [PMID:10716993] .
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129S4/SvJae * C57BL/6
Age:9.5 dpc
Theiler Stage:TS15
Mutations:Acvrl1tm1Spo/Acvrl1+
Preparation:wholemount
Procedures
General Information
Authors:Seki T; Yun J; Oh SP, 2003 [PMID:12970115] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1161/01.RES.0000095246.40391.3B] [ PMID:12970115] Seki T, Yun J, Oh SP 2003 Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res (93):682-9
 [ doi:10.1073/pnas.97.6.2626] [ PMID:10716993] Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E 2000 Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (97):2626-31
Links:MGI:2680088 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE