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EMAGE:4645

Afp alpha fetoprotein ( MGI:87951)
TS17 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:4645
Fig 9I. Copyright: This image is from Martinez Barbera JP; Clements M; Thomas P; Rodriguez T; Meloy D; Kioussis D; Beddington RS, Development 2000;127(11):2433-45 [PMID:10804184] , and is displayed with the permission of The Company of Biologist Limited who owns the Copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: lb - liver bud.
Expression Pattern Description
Spatial Annotation:
EMAGE:4645Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4645_wholemount_notDetected_3D_1.wlz
4645_wholemount_possible_3D_1.wlz
4645_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4645_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
liver
detected detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Afp probeB
Entity Detected:Afp, alpha fetoprotein ( MGI:87951)
Notes:The Afp probe used in this study by Martinez Barbera et al., 2000 [PMID:10804184] is indicated as that described by Cascio & Zaret, 1991 [PMID:1764997] . Editors note: An Afp probe is not described by Cascio & Zaret, 1991 [PMID:1764997] , only a probe for albumin (Alb) (which is also expressed in the developing liver).
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Martinez Barbera JP; Clements M; Thomas P; Rodriguez T; Meloy D; Kioussis D; Beddington RS, 2000 [PMID:10804184] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:10804184] Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS 2000 The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development (127):2433-45
 [ PMID:1764997] Cascio S, Zaret KS 1991 Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation. Development (113):217-25
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE