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EMAGE:4647

Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 ( MGI:107928)
TS17 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:4647
Fig1E. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.ydbio.2006.11.035] Dev Biol 303: 601-610, Molotkova N; Molotkov A; Duester G, Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone. Copyright 2006

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: f - forebrain telencephalic vesicle.
Expression Pattern Description
Spatial Annotation:
EMAGE:4647Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4647_wholemount_moderate.wlz
4647_wholemount_notDetected.wlz
4647_wholemount_strong.wlz
4647_wholemount_possible.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4647_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
eye
not detected not detected
homogeneousBy E10.5, Raldh2 expression is no longer observed in the eye or anywhere nearby the forebrain.
forebrain
not detected not detected
homogeneous
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Aldh1a2 probeA
Entity Detected:Aldh1a2, aldehyde dehydrogenase family 1, subfamily A2 ( MGI:107928)
Notes:The Aldh1a2 (Raldh2) probe used in this study by Molotkova et al., 2007 [PMID:17207476] is indicated as that previously described by Mic et al., 2002 [PMID:11959834] who indicate that it was prepared from the cDNA described by Haselbeck et al., 1999 [PMID:10570467] . Editors note: The method used to clone a 'full-length' cDNA clone is given by Haselbeck et al, however the actual sequence of this clone is not reported in that paper, nor is a GenBank ID given for the sequence.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Molotkova N; Molotkov A; Duester G, 2007 [PMID:17207476] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.ydbio.2006.11.035] [ PMID:17207476] Molotkova N, Molotkov A, Duester G 2007 Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone. Dev Biol (303):601-10
 [ PMID:11959834] Mic FA, Haselbeck RJ, Cuenca AE, Duester G 2002 Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development (129):2271-82
 [ doi:10.1002/(SICI)1520-6408(1999)25:4<353::AID-DVG9>3.0.CO;2-G] [ PMID:10570467] Haselbeck RJ, Hoffmann I, Duester G 1999 Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways. Dev Genet (25):353-64
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE