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EMAGE:4652

Arhgef10 Rho guanine nucleotide exchange factor (GEF) 10 ( MGI:2444453)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:4652
Fig3D. from [PMID:14508709] Am J Hum Genet 73(4): 926-932, Verhoeven K; De Jonghe P; Van de Putte T; Nelis E; Zwijsen A; Verpoorten N; De Vriendt E; Jacobs A; Van Gerwen V; Francis A; Ceuterick C; Huylebroeck D; Timmerman V, Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. Copyright 2003

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:4652Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4652_wholemount_moderate_3D_1.wlz
4652_wholemount_weak_3D_1.wlz
4652_wholemount_notDetected_3D_1.wlz
4652_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4652_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
future brain
strong strong
regionalHigh levels of GEF10 mRNA are observed in the neuroepithelium lining the brain ventricles.
future hindbrain
strong strong
regionalAt E9.5, high levels of Gef10 expression were detected in the roof plate of the rhombencephalon.
neural tube
weak weak
regional
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Arhgef10 probeA
Entity Detected:Arhgef10, Rho guanine nucleotide exchange factor (GEF) 10 ( MGI:2444453)
Notes:The Arhgef10 (GEF10) probe used in this study by Verhoeven et al., 2003 [PMID:14508709] is of unreported sequence.
Chemistry:RNA
Strand:antisense
Specimen
Organism:mouse
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Verhoeven K; De Jonghe P; Van de Putte T; Nelis E; Zwijsen A; Verpoorten N; De Vriendt E; Jacobs A; Van Gerwen V; Francis A; Ceuterick C; Huylebroeck D; Timmerman V, 2003 [PMID:14508709] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1086/378159] [ PMID:14508709] Verhoeven K, De Jonghe P, Van de Putte T, Nelis E, Zwijsen A, Verpoorten N, De Vriendt E, Jacobs A, Van Gerwen V, Francis A, Ceuterick C, Huylebroeck D, Timmerman V 2003 Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. Am J Hum Genet (73):926-32
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE