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EMAGE:4657

Arx aristaless related homeobox ( MGI:1097716)
TS17 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:4657
Fig1i. Copyright: This image is from [doi:10.1002/dvdy.20164] Colombo E; Galli R; Cossu G; Gecz J; Broccoli V, "Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons." Dev Dyn 2004 Nov;231(3):631-639, and is displayed with the permission of Wiley-Liss, Inc. who owns the Copyright.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: ba - branchial arches; fb - forebrain; hb - hindbrain; md - midbrain; s - somites; vt - ventral thalamus.
Expression Pattern Description
Spatial Annotation:
EMAGE:4657Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4657_wholemount_moderate_3D_1.wlz
4657_wholemount_weak_3D_1.wlz
4657_wholemount_notDetected_3D_1.wlz
4657_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4657_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
telencephalon
strong strong
regionalA strong expression is localized into the dorsal telencephalon restricted to the proliferative compartment. Expression is also seen in ventral thalamus.
brain
detected detected
regionalArx expression is detected in the ventral thalamus.
trunk somite
detected detected
regionalArx transcripts are detected in the developing somites.
central nervous system
detected detected
regionalArx transcripts are detected in some (neural) structures outside the forebrain like the floor plate. The authors however do not specify which part of the neural tube where the floor plate expression is found.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Arx probeA
Entity Detected:Arx, aristaless related homeobox ( MGI:1097716)
Notes:The Arx probe used in this study by Colombo et al., 2004 [PMID:15376319] is of unreported sequence.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
Staining procedure:alkaline phosphatase + BMpurple
General Information
Authors:Colombo E; Galli R; Cossu G; Gecz J; Broccoli V, 2004 [PMID:15376319] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1002/dvdy.20164] [ PMID:15376319] Colombo E, Galli R, Cossu G, Gecz J, Broccoli V 2004 Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons. Dev Dyn (231):631-9
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE