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EMAGE:4688

Btg2 B-cell translocation gene 2, anti-proliferative ( MGI:108384)
TS19 (11.5 dpc)
in situ reporter

Data Images
EMAGE:4688
Fig1C. Copyright: This image is from [doi:10.1073/pnas.0308600100] Haubensak W; Attardo A; Denk W; Huttner WB, Proc Natl Acad Sci U S A 2004 Mar 2;101(9):3196-201. [PMID:14963232] Copyright 2004 National Academy of Sciences, U.S.A.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotatsions: Arrow indicates the dorsal telencephalon; arrowhead indicates the mid-hindbrain boundary; asterisk indicates the tailbud.
Expression Pattern Description
Spatial Annotation:
EMAGE:4688Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4688_wholemount_moderate_3D_1.wlz
4688_wholemount_notDetected_3D_1.wlz
4688_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4688_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
central nervous system
detected detected
Expression is detected in the developing CNS in temporal and spatial correlation with neurogenesis.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Btg2, B-cell translocation gene 2, anti-proliferative ( MGI:108384)
Notes:Btg2 (Tis21) expression was detected in this study by Haubensak et al., 2004 [PMID:14963232] using heterozygous Tis21-GFP knock-in embryos. In the constuction of these mice, homologous recombination was used to replace the coding portion of exon 1 with GFPpA fused to a floxed neo cassette. Subsequent cre-mediated recombination removed the neo cassette, leaving GFPpA and one loxp site. Full details of the generation of the Tis21-GFP mice can be found in the supporting text of the paper.
Labelled with:GFP
Specimen
Organism:mouse
Strain:involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Age:11.5 dpc
Theiler Stage:TS19
Mutations:Btg2tm1Wbh/Btg2+
Preparation:wholemount
Procedures
Fixation:none
General Information
Authors:Haubensak W; Attardo A; Denk W; Huttner WB, 2004 [PMID:14963232] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1073/pnas.0308600100] [ PMID:14963232] Haubensak W, Attardo A, Denk W, Huttner WB 2004 Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. Proc Natl Acad Sci U S A (101):3196-201
Links:MGI:3038949 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE