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EMAGE:4726

Ccnd1 cyclin D1 ( MGI:88313)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:4726
Fig3A(wt). from Cancer Res 66(15): 7562-70, Stahl M; Ge C; Shi S; Pestell RG; Stanley P, Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Copyright 2006 [PMID:16885355]

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:4726Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4726_wholemount_moderate_3D_1.wlz
4726_wholemount_weak_3D_1.wlz
4726_wholemount_notDetected_3D_1.wlz
4726_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4726_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
telencephalon
strong strong
regionalcyclin D1 transcript levels were high in the anterior forebrain
future midbrain
strong strong
regionalcyclin D1 transcript levels were high in the posterior midbrain.
branchial arch
strong strong
ear
strong strong
regionalcyclin D1 transcript levels were high in the otic vesicles.
embryo
strong strong
regionalcyclin D1 transcript levels were high in an area immediately ventral to developing somites.
neural tube
strong strong
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Ccnd1 probeB
Entity Detected:Ccnd1, cyclin D1 ( MGI:88313)
Notes:The Ccnd1 (cyclin D1) probe used in this study by Stahl et al., 2006 [PMID:16885355] is described as "A pcDNA3 plasmid containing the mouse cyclin D1 gene coding sequence (Swiatek et al., 1994 [PMID:7926761] ; a gift from Dr. C. Sherr, Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN) linearized with BamHI." Editors note: the exact region covered by this probe is not reported.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Staining procedure:alkaline phosphatase + NBT/BCIP
General Information
Authors:Stahl M; Ge C; Shi S; Pestell RG; Stanley P, 2006 [PMID:16885355] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1158/0008-5472.CAN-06-0974] [ PMID:16885355] Stahl M, Ge C, Shi S, Pestell RG, Stanley P 2006 Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Cancer Res (66):7562-70
 [ doi:10.1101/gad.8.6.707] [ PMID:7926761] Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T 1994 Notch1 is essential for postimplantation development in mice. Genes Dev (8):707-19
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE