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EMAGE:4864

Dab1 disabled homolog 1 (Drosophila) ( MGI:108554)
TS17 (10.5 dpc)
immunohistochemistry

Data Images
EMAGE:4864 EMAGE:4864
Fig4(middle row) of [doi:10.1093/emboj/16.1.121] Howell BW; Gertler FB; Cooper JA. 1997 EMBO J 16(1): 121-32. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. [PMID:9009273] © Nature Publishing Group. Reproduced with permission from EMBO J. Fig4(middle row) of [doi:10.1093/emboj/16.1.121] Howell BW; Gertler FB; Cooper JA. 1997 EMBO J 16(1): 121-32. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. [PMID:9009273] © Nature Publishing Group. Reproduced with permission from EMBO J.

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:4864Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
4864_wholemount__moderate.wlz
4864_wholemount__possible.wlz
4864_wholemount__notDetected.wlz
4864_wholemount__strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:4864_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
nervous system
detected detected
regionalmDab1 expression was observed in the head in neural tracts corresponding to the developing cranial nerves, such as the oculomotor (III) and the trochlear (IV) nerves.
dorsal root ganglion
detected detected
spinal nerve
detected detected
regionalIn the body, mDab1 expression in the spinal accessory nerve and dorsal root ganglia was apparent.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:antibody
Identifier:Dab1 antibodyA
Entity Detected:Dab1, disabled homolog 1 (Drosophila) ( MGI:108554)
Notes:The anti-Dab1 antibody used in this study by Howell et al., 1997 [PMID:9009273] was "anti-mDab(B3)", which was raised against "a GST-mDab1 fusion corresponding to residues 107-243 (B3)." Editors Note: there are three isoforms of the Dab1 protein mentioned by the authors: mDab555, mDab217, mDab271. It is not stipulated which isoform the numbering refers to.
Antibody Type:polyclonal
Raised In:rabbit
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Secondary Antibody:goat anti-rabbit
Tertiary Antibody:donkey anti-goat
Labelled with:fluorescein isothiocyanate
Visualisation method:fluorescence
General Information
Authors:Howell BW; Gertler FB; Cooper JA, 1997 [PMID:9009273] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1093/emboj/16.1.121] [ PMID:9009273] Howell BW, Gertler FB, Cooper JA 1997 Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J (16):121-32
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE