EMAGE mouse gene expression spatial database

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EMAGE:4917

Rdh10 retinol dehydrogenase 10 (all-trans) ( MGI:1924238)
TS15 (9.5 dpc)
in situ hybridisation

Data Images


Fig2A. Copyright: This image is from [doi:10.1002/dvdy.21312] Cammas L; Romand R; Fraulob V; Mura C; Dolle P. "Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation." Dev Dyn 2007 Oct;236(10):2899-908. Reprinted with permission of Wiley-Liss Inc. [PMID:17849458] .	Fig2B. Copyright: This image is from [doi:10.1002/dvdy.21312] Cammas L; Romand R; Fraulob V; Mura C; Dolle P. "Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation." Dev Dyn 2007 Oct;236(10):2899-908. Reprinted with permission of Wiley-Liss Inc. [PMID:17849458] .	Fig2C. Copyright: This image is from [doi:10.1002/dvdy.21312] Cammas L; Romand R; Fraulob V; Mura C; Dolle P. "Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation." Dev Dyn 2007 Oct;236(10):2899-908. Reprinted with permission of Wiley-Liss Inc. [PMID:17849458] .	Fig2D. Copyright: This image is from [doi:10.1002/dvdy.21312] Cammas L; Romand R; Fraulob V; Mura C; Dolle P. "Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation." Dev Dyn 2007 Oct;236(10):2899-908. Reprinted with permission of Wiley-Liss Inc. [PMID:17849458] .	Fig2E. Copyright: This image is from [doi:10.1002/dvdy.21312] Cammas L; Romand R; Fraulob V; Mura C; Dolle P. "Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation." Dev Dyn 2007 Oct;236(10):2899-908. Reprinted with permission of Wiley-Liss Inc. [PMID:17849458] .

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Note: b1, first branchial arche; dm, fg, foregut; flb, forelimb bud; lpm, lateral plate mesoderm; mn, mesonephros; ot, otocyst; so, somite.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

4917_wholemount_moderate_3D_1.wlz

4917_wholemount_notDetected_3D_1.wlz

4917_wholemount_strong_3D_1.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:4917_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

trunk somite

detected

regional

Somites posterior to the forelimb level were only weakly labeled, suggesting that Rdh10 induction declines after formation of approximately the first 10 somite pairs. With Respect to differentiation of somitic mesoderm, transverse sections at trunk levels show that only the dorsal edge of the dermomyotome, together with cells surrounding the dorsal spinal cord, were labeled.

future hindbrain

weak

regional

At the mid-hindbrain boundary area. Expressed also in some other regions of the hindbrain. At posterior hindbrain levels, only the dorsal superficial mesenchyme was positive

future midbrain

weak

regional

At the mid-hindbrain boundary area.

future spinal cord

detected

regional

Expressed in some cells in the posterior spinal cord.

optic vesicle

detected

regional

Expressed dorsally.

otocyst

detected

regional

Restricted to cells along the hindbrain surface.

forelimb bud

detected

regional

Labeled cells were seen along the entire proximal margin of the buds. Additionally, Rdh10-expressing cells extended along both the anterior and posterior margins of the growing buds, and labeling was most intense in the posterior area known as the zone of polarizing activity.

mesenchyme derived from somatopleure

strong

mesenchyme derived from splanchnopleure

strong

mesonephros

strong

regional

Expression was specific to the mesonephric ducts within the intermediate mesoderm.

rest of foregut mesenchyme

detected

regional

Highest labeling was in the mesenchyme surrounding the foregut and dorsal aortae.

dorsal aorta

detected

regional

High labeling was in the mesenchyme surrounding the dorsal aortae, dorsally to the atrial chambers of the developing heart.

foregut

strong

regional

Discrete areas of foregut endoderm also expressed Rdh10, including at the level of the second branchial arch.

midgut

detected

At more posterior levels, section analysis clearly showed endoderm-specific expression at the prospective stomach level.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	T4416
Entity Detected:	Rdh10, retinol dehydrogenase 10 (all-trans) ( MGI:1924238)
Sequence:	sense strand is shown >T4416 CTCGGGGGCGGACTCCGGGCGCAGCCTTCGCGTCCGGATCGCGGTGACAAGCGCCTCCGGGGCCAGGAGC TGGGCTGTCTGGCGCAGGGAGAGTGAGGACACGGTGCTGGGCTGCTGCGGGACCCGGGGCGTCGCGATGA ACATCGTAGTGGAGTTCTTCGTGGTCACTTTCAAAGTGCTGTGGGCGTTCGTGCTGGCCGCGGCGCGCTG GCTGGTGCGGCCCAAGGAGAAGAGCGTGGCCGGCCAGGTGTGCCTCATCACGGGCGCGGGCAGCGGCCTG GGCCGCCTCTTTGCTCTCGAGTTCGCCCGGCGCCGGGCGCTGCTGGTTCTCTGGGACATCAACACGCAGA GCAATGAGGAGACCGCAGGCATGGTTCGCCACATCTACCGGGACCTGGAGGCGGCCGACGCTGCTGCTCT GCAAGCTGGAAAAGGTGAGGAGGAAATCCTGCCCCCGTGTAACTTACAGGTTTTTACCTACACTTGTGAC GTGGGGAAGAGAGAGAATGTCTACCTGACAGCTGAAAGGGTCCGCAAGGAGGTTGGCGAGGTCTCGGTCC TGGTCAATAATGCTGGTGTGGTTTCTGGACATCACCTTCTGGAATGTCCTGATGAGCTCATTGAAAGAAC CATGATGGTCAACTGCCACGCACACTTCTGGACCACTAAGGCCTTTCTTCCAACGATGCTAGAGATTAAT CATGGCCACATTGTGACGGTCGCGAGCTCCCTGGGACTGTTCAGCACTGCTGGAGTTGAGGATTACTGTG CCAGTAAATTTGGAGTTGTGGGTTTTCACGAGTCTCTGAGCCATGAGCTAAAGGCTGCTGAAAAGGATGG AATTAAAACAACTCTGGTTTGCCCTTACCTTGTAGACACGGGCATGTTCAGAGGCTGCCGAATCAGAAAA GAAATTGAGCCCTTTTTGCCCCCCTTGAAGCCTGATTACTGTGTGAAGCAGGCTATGAGGGCCATCCTCA CTGACCAGCCCATGGTCTGCACCCCCCGCCTCATGTACATCGTGACATTCATGAAGAGCATCCTTCCTTT TGAAGCCGTCGTGTGCATGTATCGATTTCTAGGAGCGGACAAGTGTATGTATCCCTTTATTGCTCAAAGA AAACAAGCCACAAACAACAATGAAGCAAAAAATGGAATCTAAGAGTGTTTTTGTACGGAGTGCCGTTTCT ATCAGGATAGGTGGTCCGTGCGCATCAATCAGTACTGACGGTCTGGATTCTAACCCCATGCCGACTCTTT TTTTTTTTTTCTAATCAACTTTTTAAAAAATAAAGTGTAAATTAACTGACTAGTGTGCTTGAAAACTGTG AGCTTGGGTTTTTGCCAATGGGGTCTTTTCTAGACAGGGCCCTAAAAATGAGTCCAATATTTAGACAAAC ACTATGTTACATCATTATTTTTTTAATGAACATAAAGTCTAGAAATGATGACTACAGTGTGTTTCACGTG GGTCCCCACAGAATTGATTCATTCATTATCGTGGAAGCCCAGCCAGCATTCAAGGACCGACAGTGTAGTG CTCTGTTGTGTTCTCGGTTCTTCTCCTGCAAGCCTGGGTGGCTTGCTTATGGTGTCTGTGGATTTTTTGA TGTCAGTTTGAGATCAGCGTAGTCTGAGCATCACAATGAAGGCCACCAGTCTCTTTCTTAAACTTACAGT GACTAAATATTGGGTGATTTTCAAATTCAGTCTCTGAAATACTAAATTAAATGTTTAGAGACCTGGTTAA TCCACGTTTGTACATTTTCTACCTGTGAATCTTGCTGCATATAGAAAGTGCCCTTTCCTCACGGAGCTGC AAACTTGTGTTAGGGGAGGAAGTGGGGGATCTTGTCTACAGGACACAGCAGCTCCACAGAGATAATGGGA ATTTCTGATTAAAAAGTCCCCGTACTTGTGCCAACTTTAATTAGCTTGGGGAGCAAATCTTATATGGAGT GTTGTGGAAGGGTGGAAAGATTTCTTTGAAAAGTTTATTCACATTGTAGAACAGCAAATGACATTTTTAC AGTATTTTTTTGTAAAGCAAACTATTTTGTGCCTTGAATTTGGTATATGTGTATTAGTGAAACATTGTAA AAGTGAATTTCTACCTCTGTATCTATGTGTACCATCCTCTTGTAAATTACTATGAACTACTATGTGATTG CTTCTGTTTGTTCGTTCTAGGATGTCTTTTTTAAATAGTGACCAATGTTTAAGGCTGTTAAAATAAGCCA ACTTTTACAAATCGGGATGTTTTCTAAAGAACTGATTAAATACGTACATAACTG
	nt 1 - nt 2294 of NM_133832.3
Notes:	The Rdh10 probe template used in this study by Cammas et al., 2007 [PMID:17849458] was provided by Drs. C. Thaller and G. Eichele, and the EURExpress consortium. Editors Note: information from www.eurexpress.org lists the Rdh10 template as T4416, which extends from nt 1-2295 of NM_133832.3.
Chemistry:	RNA
Strand:	antisense

Specimen

Organism:	mouse
Strain:	CD-1
Age:	9.5 dpc
Theiler Stage:	TS15
Mutations:	none (wild-type)
Preparation:	wholemount

Procedures

General Information

Authors:	Cammas L; Romand R; Fraulob V; Mura C; Dolle P, 2007 [PMID:17849458] . Indexed and spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1002/dvdy.21312] [ PMID:17849458] Cammas L, Romand R, Fraulob V, Mura C, Doll� P 2007 Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation. Dev Dyn (236):2899-908
Links:	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source