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EMAGE:5042

Shfm1 split hand/foot malformation (ectrodactyly) type 1 ( MGI:109238)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:5042
Figure 4A. Crackower MA; Scherer SW; Rommens JM; Hui CC; Poorkaj P; Soder S; Cobben JM; Hudgins L; Evans JP; Tsui LC, "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development." Hum Mol Genet 1996 May;5(5):571-9. [PMID:8733122]

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:5042Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5042_wholemount_moderate_3D_1.wlz
5042_wholemount_possible_3D_1.wlz
5042_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5042_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
1st branchial arch mandibular component mesenchyme
strong strong
1st branchial arch maxillary component mesenchyme
strong strong
fronto-nasal process mesenchyme
strong strong
forelimb bud mesenchyme
detected detected
hindlimb ridge mesenchyme
detected detected
forelimb bud ectoderm
not detected not detected
homogeneous
hindlimb ridge ectoderm
not detected not detected
homogeneous
future brain
detected detected
Expressed in cephalic regions.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Shfm1 probeA
Entity Detected:Shfm1, split hand/foot malformation (ectrodactyly) type 1 ( MGI:109238)
Notes:The Shfm1 (Dss1) probe used in this study by Crackower et al., 1996 [PMID:8733122] was "a digoxigenin-labeled RNA probe", which is of unreported sequence.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Strain:CD-1
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Crackower MA; Scherer SW; Rommens JM; Hui CC; Poorkaj P; Soder S; Cobben JM; Hudgins L; Evans JP; Tsui LC, 1996 [PMID:8733122] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1093/hmg/5.5.571] [ PMID:8733122] Crackower MA, Scherer SW, Rommens JM, Hui CC, Poorkaj P, Soder S, Cobben JM, Hudgins L, Evans JP, Tsui LC 1996 Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. Hum Mol Genet (5):571-9
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE