EMAGE mouse gene expression spatial database

EMAGE:5118

Sulf2 sulfatase 2 ( MGI:1919293)
TS19 (11.5 dpc)
in situ reporter

Data Images


Fig5A of [doi:10.1128/MCB.01279-06] Mol Cell Biol 2007 27(2):678-688 [PMID:17116694] Lum DH; Tan J; Rosen SD; Werb Z, "Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2." © ASM. Reproduced with permission from Molecular and Cellular Biology. Reuse of any Licensed Material requires permission from ASM. Copyright 2007.

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Some heterozygous pups (2/8 total runted pups) are severely runted with weights ~50% that of littermates at birth.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

wholemount mapping

Download individual expression domains:

Download all expression domains:

Find spatially similar wholemount expression patterns:

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

embryo

detected

Expressed broadly in the embryo. No expression in the yolk sac.

skeleton

detected

dorsal root ganglion

detected

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ reporter
Entity Detected:	Sulf2, sulfatase 2 ( MGI:1919293)
Notes:	Sulf2 expression in this study by Lum et al., 2007 [PMID:17116694] was assayed in embryos heterozygous for a gene trap mutation whereby the pGT1TMpfs vector was inserted into intron 5. The resulting protein lacked the C-terminal 629 amino acids including the catalytic cysteine essential for sulfatase activity and a hydrophilic domain necessary for sulfatase activity and HS binding. Gene trap XST155, BayGenomics.
Labelled with:	LacZ

Specimen

Procedures

General Information

Authors:	Lum DH; Tan J; Rosen SD; Werb Z. 2007 [PMID:17116694] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1128/MCB.01279-06] [ PMID:17116694] Lum DH, Tan J, Rosen SD, Werb Z 2007 Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol (27):678-88
Links:	MGI:3697687 allele description
	MGI:3699397 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source