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EMAGE:5225

Ednrb endothelin receptor type B ( MGI:102720)
TS17 (10.5 dpc)
in situ reporter

Data Images
EMAGE:5225
Fig7D(left). Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0012-1606(03)00160-X] Dev Biol 259(1): 162-75, Lee HO; Levorse JM; Shin MK, The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors. Copyright 2003 [PMID:12812796]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: Arrowhead indicates the expression in the developing heart and arrow indicates the expression in the neural tube.
Expression Pattern Description
Spatial Annotation:
EMAGE:5225Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5225_wholemount_moderate_3D_1.wlz
5225_wholemount_weak_3D_1.wlz
5225_wholemount_notDetected_3D_1.wlz
5225_wholemount_strong_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5225_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
head mesenchyme derived from neural crest
detected detected
expression is detected in migrating neural crest cells throughout the rostrocaudal axis of the embryo.
hindbrain
detected detected
regionalExpressing cells were detected through the cranial mesenchyme and into the hindbrain through distinct rhombomere entry sites.
acoustic viii ganglion
detected detected
facial vii ganglion
detected detected
glossopharyngeal ix ganglion
detected detected
trigeminal v ganglion
detected detected
vagus x ganglion
detected detected
trunk somite
detected detected
regionallabeled NCCs were observed in the rostral half of the somites that will eventually give rise to dorsal root ganglia (DRG).
dorsal root ganglion
detected detected
peripheral nervous system
detected detected
regionallabeled NCCs were observed in the sympathetic ganglia chain (SC) and in enteric neuron precursors. Expression is also detected in peripheral nerves including the intercostals and the nerves in the limbs.
spinal nerve
detected detected
Expressed in peripheral nerves including the intercostals and the nerves in the limbs
trunk mesenchyme derived from neural crest
detected detected
expression is detected in migrating neural crest cells throughout the rostrocaudal axis of the embryo.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Ednrb, endothelin receptor type B ( MGI:102720)
Notes:Ednrb expression was assayed in this study by Lee et al., 2003 [PMID:12812796] in embryos heterozygous for a targeted mutation where the targeting vector was designed to insert a LacZ into exon 1 immediately downstream of the ATG, replacing sequence encoding the extracellular domain and the first two transmembrane spanning domains. Cre mediated excision removed a floxed neo.
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129P2/OlaHsd
Age:10.5 dpc
Theiler Stage:TS17
Mutations:Ednrbtm1Myks/Ednrb+
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
General Information
Authors:Lee HO; Levorse JM; Shin MK, 2003 [PMID:12812796] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/S0012-1606(03)00160-X] [ PMID:12812796] Lee HO, Levorse JM, Shin MK 2003 The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors. Dev Biol (259):162-75
Links:MGI:3640402 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE