EMAGE mouse gene expression spatial database

EMAGE:5328

Fbl fibrillarin ( MGI:95486)
TS19 (11.5 dpc)
in situ reporter

Data Images


Fig5A(11.5) of [doi:10.1128/MCB.23.23.8519-8527.2003] Mol Cell Biol 2003 23(23):8519-8527 [PMID:14612397] Newton K; Petfalski E; Tollervey D; Caceres JF, "Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse." � ASM. Reproduced with permission from Molecular and Cellular Biology. Reuse of any Licensed Material requires permission from ASM. Copyright 2003.

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

wholemount mapping

Download individual expression domains:

Download all expression domains:

Find spatially similar wholemount expression patterns:

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

neural tube

detected

Fbl expression was restricted to highly proliferating tissues such as neural tube and limb buds.

limb

detected

Fbl expression was restricted to highly proliferating tissues such as neural tube and limb buds.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ reporter
Entity Detected:	Fbl, fibrillarin ( MGI:95486)
Notes:	Fbl (Fibrillarin) expression was assayed in this study by Newton et al., 2003 [PMID:14612397] in embryo heterozygous for a gene trapped allele, where the endogenous locus was disrupted by insertion into intron 4 of the pGT1,-2, or-3 retroviral gene trap vector containing a splice acceptor site, beta-geo, and an SV40 poly-A signal. A fusion protein consisting of the N-terminal 132 amino acids of the Fbl protein fused to lacZ is expressed from the mutated locus.
Labelled with:	LacZ

Specimen

Procedures

Fixation:

0.5% glutaraldehyde

General Information

Authors:	Newton K; Petfalski E; Tollervey D; Caceres JF, 2003 [PMID:14612397] , Indexed and Spatially Mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1128/MCB.23.23.8519-8527.2003] [ PMID:14612397] Newton K, Petfalski E, Tollervey D, Caceres JF 2003 Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol Cell Biol (2003):8519-27
Links:	MGI:3043754 allele description
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source