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EMAGE:5400

Hdac7 histone deacetylase 7 ( MGI:1891835)
TS19 (11.0 dpc)
in situ reporter

Data Images
EMAGE:5400
Figure 2Bb. Copyright: Reprinted with permission from Cell Press from [doi:10.1016/j.cell.2006.05.040] Cell 126: 321-34, Chang S; Young BD; Li S; Qi X; Richardson JA; Olson EN, "Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10." Copyright 2006 [PMID:16873063]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:5400Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5400_wholemount__moderate.wlz
5400_wholemount__weak.wlz
5400_wholemount__notDetected.wlz
5400_wholemount__strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5400_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
arterial system
detected detected
predominantly expressed in large and small vessels, arteries and veins, and the heart.
heart
detected detected
predominantly expressed in large and small vessels, arteries and veins, and the heart.
venous system
detected detected
predominantly expressed in large and small vessels, arteries and veins, and the heart.
neural tube
weak weak
Low expression in neural tube was observed
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Hdac7, histone deacetylase 7 ( MGI:1891835)
Notes:Hdac7 expression was assayed in this study by Chang et al., 2006 [PMID:16873063] in embryos heterozygous for a targeted allele where exons 2-5, including the MEF2 binding domain, were replaced with a promoter-less lacZ-neo cassette in frame with exon 2. RT-PCR confirmed absence of transcript from mutant mice.
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129/Sv * C57BL/6
Age:11.0 dpc
Theiler Stage:TS19
Mutations:Hdac7tm1Eno/Hdac7+
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
General Information
Authors:Chang S; Young BD; Li S; Qi X; Richardson JA; Olson EN, 2006 [PMID:16873063] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.cell.2006.05.040] [ PMID:16873063] Chang S, Young BD, Li S, Qi X, Richardson JA, Olson EN 2006 Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell (126):321-34
Links:MGI:3693627 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE