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EMAGE:5805

Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 ( MGI:96673)
TS15 (9.5 dpc)
in situ reporter

Data Images
EMAGE:5805
Figure 1B. [doi:10.1172/JCI19846] Jay PY; Harris BS; Maguire CT; Buerger A; Wakimoto H; Tanaka M; Kupershmidt S; Roden DM; Schultheiss TM; O'Brien TX; Gourdie RG; Berul CI; Izumo S, "Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system." J Clin Invest 2004; 113: 1130-7. [PMID:15085192]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:5805Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5805_wholemount__possible.wlz
5805_wholemount__notDetected.wlz
5805_wholemount__strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5805_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
atrioventricular canal
detected detected
regionalExpressed in the inner curvature of the AV canal.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Kcne1, potassium voltage-gated channel, Isk-related subfamily, member 1 ( MGI:96673)
Notes:Kcne1 (minK) expression was revealed in this study by Jay et al., 2004 [PMID:15085192] in an embryo heterozygous for a targeted allele where the entire coding region, contained in exon 2, was replaced with an NLS-lacZ-pA PGK-neo cassette. Construction of the mutant allele is described by Kupershmidt et al, [PMID:9933245] .
Labelled with:LacZ
Specimen
Organism:mouse
Strain:129S6/SvEvTac
Age:9.5 dpc
Theiler Stage:TS15
Mutations:Kcne1tm1Rdn/Kcne1+
Preparation:wholemount
Procedures
General Information
Authors:Jay PY; Harris BS; Maguire CT; Buerger A; Wakimoto H; Tanaka M; Kupershmidt S; Roden DM; Schultheiss TM; O'Brien TX; Gourdie RG; Berul CI; Izumo S, 2004 [PMID:15085192] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1172/JCI19846] [ PMID:15085192] Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O'Brien TX, Gourdie RG, Berul CI, Izumo S 2004 Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest (113):1130-7
 [ PMID:9933245] Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM 1999 Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res (84):146-52
Links:MGI:3040614 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE