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EMAGE:5832

Frzb frizzled-related protein ( MGI:892032)
TS14 (8.75 dpc)
in situ hybridisation

Data Images
EMAGE:5832 EMAGE:5832 EMAGE:5832
Fig2c. Copyright: This image is from [doi:10.1002/(SICI)1097-0177(199807)212:3<364::AID-AJA4>3.0.CO;2-F] Hoang BH; Thomas JT; Abdul-Karim FW; Correia KM; Conlon RA; Luyten FP; Ballock RT, Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn 1998 Jul;212(3):364-72. Reprinted with permission of Wiley-Liss Inc. [PMID:9671940] . Fig2e. Copyright: This image is from [doi:10.1002/(SICI)1097-0177(199807)212:3<364::AID-AJA4>3.0.CO;2-F] Hoang BH; Thomas JT; Abdul-Karim FW; Correia KM; Conlon RA; Luyten FP; Ballock RT, Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn 1998 Jul;212(3):364-72. Reprinted with permission of Wiley-Liss Inc. [PMID:9671940] . Fig2f. Copyright: This image is from [doi:10.1002/(SICI)1097-0177(199807)212:3<364::AID-AJA4>3.0.CO;2-F] Hoang BH; Thomas JT; Abdul-Karim FW; Correia KM; Conlon RA; Luyten FP; Ballock RT, Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn 1998 Jul;212(3):364-72. Reprinted with permission of Wiley-Liss Inc. [PMID:9671940] .

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: BA, branchial arch; CM, cardiac mesoderm; FB, forebrain; PS, primitive streak. Fig2e:arrow signifies expression in the forebrain, arrowhead signifies expression in the midbrain. Fig2f: bracket signifies presomitic mesoderm, arrowheads indicate the somites. Fig2E and F show the head and tail at higher magnification.
Expression Pattern Description
Spatial Annotation:
EMAGE:5832Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5832_wholemount__moderate.wlz
5832_wholemount__notDetected.wlz
5832_wholemount__strong.wlz
5832_wholemount__possible.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5832_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
unsegmented mesenchyme
detected detected
mFrzb-1 is seen in the presomitic mesoderm from which developing somites are formed.
trunk somite
detected detected
regionalmFrzb-1 is expressed in the cranial halves of newly formed somites.
primitive streak
not detected not detected
homogeneousmFrzb-1 expression in the primitive streak is rather transitory, and by 8.75 dpc, the expression here is no longer detected.
future midbrain
detected detected
regionalmFrzb-1 is found in the dorsal cells of the neural tube in the presumptive midbrain and forebrain at 8.75 dpc.
prosencephalon
detected detected
regionalmFrzb-1 is found in the dorsal cells of the neural tube in the presumptive midbrain and forebrain at 8.75 dpc.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Frzb probeA
Entity Detected:Frzb, frizzled-related protein ( MGI:892032)
Notes:The Frzb (mFrzb-1) probe used in this study by Hoang et al., 1998 [PMID:9671940] is described as follows: "mFrzb-1 was linearized with NotI and transcribed with T7 RNA polymerase for the antisense probe." Editors Note: several Frzb clones are described by Hoang et al., and it is not specified which one is referred to above.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Strain:CD-1
Age:8.75 dpc
Theiler Stage:TS14
Mutations:none (wild-type)
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
Staining procedure:alkaline phosphatase + NBT/BCIP
General Information
Authors:Hoang BH; Thomas JT; Abdul-Karim FW; Correia KM; Conlon RA; Luyten FP; Ballock RT, 1998 [PMID:9671940] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1002/(SICI)1097-0177(199807)212:3<364::AID-AJA4>3.0.CO;2-F] [ PMID:9671940] Hoang BH, Thomas JT, Abdul-Karim FW, Correia KM, Conlon RA, Luyten FP, Ballock RT 1998 Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn (212):364-72
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE