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EMAGE:5855

Gdnf glial cell line derived neurotrophic factor ( MGI:107430)
TS16 (30 Somite no.)
in situ reporter

Data Images
EMAGE:5855
Fig1A. Copyright: Reprinted with permission from Cell Press from [doi:10.1016/S0896-6273(02)00864-4] Neuron 35(5): 893-905, Haase G; Dessaud E; Garces A; de Bovis B; Birling M; Filippi P; Schmalbruch H; Arber S; deLapeyriere O, GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Copyright 2002. [PMID:12372284]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Image annotations: arrowhead indicates localized expression in the proximal part of the forelimb bud. NOTE - this embryo has been eviscerated.
Expression Pattern Description
Spatial Annotation:
EMAGE:5855Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5855_wholemount__moderate.wlz
5855_wholemount__weak.wlz
5855_wholemount__notDetected.wlz
5855_wholemount__strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5855_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
forelimb bud
detected detected
regionalExpression was detected in the proximal part of the forelimb bud.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Gdnf, glial cell line derived neurotrophic factor ( MGI:107430)
Notes:Gdnf expression was assayed in this study by Haase et al., 2002 [PMID:12372284] in embryos heterozygous for a targeted allele where a lacZ gene followed by a neomycin cassette was inserted in frame after the codon corresponding to amino acid 102. This allele expresses a fusion protein consisting of the first 102 amino acids of GDNF fused to beta-galactosidase.
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129S2/SvPas * CD-1
Age:30 Somite no.
Theiler Stage:TS16
Mutations:Gdnftm1Rosl/Gdnf+
Preparation:wholemount
Procedures
General Information
Authors:Haase G; Dessaud E; Garces A; de Bovis B; Birling M; Filippi P; Schmalbruch H; Arber S; deLapeyriere O, 2002 [PMID:12372284] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/S0896-6273(02)00864-4] [ PMID:12372284] Haase G, Dessaud E, Garces A, de Bovis B, Birling M, Filippi P, Schmalbruch H, Arber S, deLapeyriere O 2002 GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron (2002):893-905
Links:MGI:2136843 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE