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EMAGE:5857

Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 ( MGI:1201403)
TS18 (10.5 dpc)
in situ reporter

Data Images
EMAGE:5857
Figure8B(wm) from [doi:10.1080/01926230490431475] Toxicol Pathol 32(3):275-94. Bolon B; Jing S; Asuncion F; Scully S; Pisegna M; Van GY; Hu Z; Yu YB; Min H; Wild K; Rosenfeld RD; Tarpley J; Carnahan J; Duryea D; Hill D; Kaufman S; Yan XQ; Juan T; Christensen K; McCabe J; Simonet WS. The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Copyright 2004. [PMID:15204970]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:5857Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5857_wholemount__moderate.wlz
5857_wholemount__notDetected.wlz
5857_wholemount__strong.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5857_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: one star
Text Annotation:
StructureLevelPatternNotes
dorsal root ganglion
detected detected
regionalBy E10.5, the diffuse staining was coalescing into focal condensations representing the DRG (dorsal root ganglia) and their ventral roots, chiefly in the thoracolumbar region.
trigeminal v ganglion
detected detected
peripheral nerve trunk
detected detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Gfra3, glial cell line derived neurotrophic factor family receptor alpha 3 ( MGI:1201403)
Notes:Gfra3 expression was assayed in this study by Bolon et al., 2004 [PMID:15204970] in embryos heterozygous for a targeted allele where an 11 kb segment of the gene including exons 1 and 2 and encoding amino acids 2 to 123 was replaced with a lacZ/neo cassette. The cassette was fused in frame. See Figure 1 of Bolon et al., 2004 [PMID:15204970] for details.
Labelled with:LacZ
Specimen
Organism:mouse
Strain:involves: 129X1/SvJ * Black Swiss
Age:10.5 dpc
Theiler Stage:TS18
Mutations:Gfra3tm1Wss/Gfra3+
Preparation:wholemount
Procedures
General Information
Authors:Bolon B; Jing S; Asuncion F; Scully S; Pisegna M; Van GY; Hu Z; Yu YB; Min H; Wild K; Rosenfeld RD; Tarpley J; Carnahan J; Duryea D; Hill D; Kaufman S; Yan XQ; Juan T; Christensen K; McCabe J; Simonet WS, 2004 [PMID:15204970] , Indexed and Spatially Mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1080/01926230490431475] [ PMID:15204970] Bolon B, Jing S, Asuncion F, Scully S, Pisegna M, Van GY, Hu Z, Yu YB, Min H, Wild K, Rosenfeld RD, Tarpley J, Carnahan J, Duryea D, Hill D, Kaufman S, Yan XQ, Juan T, Christensen K, McCabe J, Simonet WS 2004 The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol (32):275-94
Links:MGI:3045508 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE