EMAGE mouse gene expression spatial database

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EMAGE:5912

Dpysl3 dihydropyrimidinase-like 3 ( MGI:1349762)
TS15 (9.5 dpc)
in situ hybridisation

Data Images


Figure 4G. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.mod.2008.04.006] Mech Dev 125: 687-99, Heanue TA; Pachnis V, "Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species."Copyright 2008. [PMID:18565740]

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Image annotation: area bounded by hatch marks - developing foregut.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

5912_wholemount__moderate.wlz

5912_wholemount__weak.wlz

5912_wholemount__notDetected.wlz

5912_wholemount__strong.wlz

5912_wholemount__possible.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:5912_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

nervous system

detected

There is no expression in the enteric precursors colonizing the developing foregut but there is expression in some neural domains outwith the enteric nervous system

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:1827925
Entity Detected:	Dpysl3, dihydropyrimidinase-like 3 ( MGI:1349762)
Sequence:	sense strand is shown >MGI:1827925 GGGCAGACATCCCCTGCAGCCAGAATCGCCACCATGTCCTACCAGGGCAAGAAGAACATTCCGCGGATCA CGAGTGACCGTCTTCTAATCAAGGGAGGGAGAATCGTCAATGATGATCAGTCCTTTTATGCTGATATTTA CATGGAGGATGGCTTAATAAAGCAAATTGGAGACAATCTGATTGTCCCCGGAGGTGTGAAGACCATCGAG GCCAACGGGAAGATGGTGATCCCTGGAGGCATTGACGTCCATACCCACTTCCAGATGCCTTACAAGGGAA TGACCACAGTGGACGATTTCTTCCAAGGGACAAAGGCTGCCTTAGCGGGAGGCACCACCATGATCATTGA CCACGTGGTACCTGAACCTGAGTCTAGCCTGACAGAGGCCTATGAAAAGTGGCGTGAGTGGGCCGATGGG AAGAGCTGCTGTGACTATGCTTTGCATGTGGACATCACCCACTGGAATGACAGCGTCAAGCAGGAGGTAC AGAGCCTCAGCAAGGAAAAAGGCGTTAACTCCTTCATGGTTTACATGGCCTACAAGGATTTATATCAAGT GTCCAACACAGAGCTCTATGAGATCTTCACCTGCCTGGGAGAGCTGGGGGCCATTGCTCAAGTTCATGCC GAGAATGGAGATATCATTGCCCAGGAGCAGGCACGGATGCTGGAAATGGGGATAACCGGCCCAGAAGGCC ACGTTCTGAGCAGACCGGAAGAGCTGGAAGCTGAGGCTGTGTTCCGTGCCATCACCGTCGCCAGCCAGAC CAACTGCCCCCTCTATGTCACCAAGGTCATGAGCAAGAGCGCGGCTGATCTCATCTCACAAGCCAGGAAG AAAGGAAATGTGGTCTTTGGCGAGCCCATCACTGCCAGCCTGGGAATAGATGGAACTCATTACTGGAGTA AGAACTGGGCCAAAGCAGCTGCGTTTGTGACATCCCCACCTCTGAGCCCTGACCCTACCACACCTGACTA CATCAACTCCTTGCTGGCCAGCGGGGATCTGCAGCTCTCTGGAAGTGCCCACTGTACCTTTAGCACTGCC CAGAAAGCCATTGGGAAGGACAACTTCACAGCCATCCCTGAAGGCACCAATGGCGTGGAGGAGCGTATGT CTGTCATCTGGGACAAGGCTGTGGCCACGGGGAAGATGGATGAAAACCAGTTTGTGGCCGTGACAAGCAC CAATGCTGCCAAGATATTCAACCTGTACCCTCGAAAGGGGAGAATAGCTGTGGGCTCTGACAGCGACCTT GTCATCTGGGATCCAGATGCCTTGAAGATTGTCTCTGCCAAGAACCACCAGTCGGTTGCCGAATACAACA TCTTTGAAGGGATGGAGCTGCGTGGTGCACCTCTGGTGGTTATCTGCCAGGGCAAGATCATGCTGGAAGA TGGCAACCTGCACGTGACCCAGGGGGCTGGCCGCTTCATTCCCTGCAGCCCATTCTCTGACTATGTCTAT AAGCGCATTAAAGCAAGGAGGAAGATGGCAGACCTGCATGCAGTCCCAAGAGGCATGTATGATGGACCAG TGTTTGACTTGACCACCACCCCCAAGGGGGGCACCCCAGCTGGCTCTACTCGGGGCTCTCCCACTCGGCC AAACCCGCCAGTGAGGAACCTCCATCAGTCAGGATTTAGCCTGTCAGGCACCCAAGTGGATGAGGGTGTC CGCTCAGCTAGCAAACGCATTGTGGCACCCCCTGGAGGCCGTTCTAACATCACATCCCTGAGTTAAGCCC TCCCAAAGAGGGAGGCAGAAGCAAAAAAAAAAAAA
	nt 1 - nt 1785 of BC023003.1
Notes:	The Dpysl3 probe used in this study by Heanue & Pachnis, 2008 [PMID:18565740] is indicated as that originally described by Heanue & Pachnis, 2006 [PMID:16632597] i.e. generated using the clone IMAGE 5367381 as a template, digested with SalI and polymerised with T7.
Chemistry:	RNA
Strand:	antisense

Specimen

Organism:	mouse
Age:	9.5 dpc
Theiler Stage:	TS15
Mutations:	none (wild-type)
Preparation:	wholemount

Procedures

General Information

Authors:	Heanue TA & Pachnis V, 2008 [PMID:18565740] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1016/j.mod.2008.04.006] [ PMID:18565740] Heanue TA, Pachnis V 2008 Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Mech Dev (125):687-99
	[ doi:10.1073/pnas.0602152103] [ PMID:16632597] Heanue TA, Pachnis V 2006 Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A (103):6919-24
Links:	MGI:3814912 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source