EMAGE mouse gene expression spatial database

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EMAGE:5936

Lingo1 leucine rich repeat and Ig domain containing 1 ( MGI:1915522)
TS18 (10.5 dpc)
in situ hybridisation

Data Images


Figure 2I. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2J. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2K. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2L. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2M. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]

Figure 2N. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2O. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2P. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2Q. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2R. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]

Figure 2S. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]	Figure 2T. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.modgep.2007.10.003] Gene Expr Patterns 2008; 8: 79-86 Haines BP; Rigby PW, "Expression of the Lingo/LERN gene family during mouse embryogenesis." Copyright 2008. [PMID:18297755]

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Note: trigeminal (tg), facio-acoustic (fa) and the dorsal root (drg) ganglia; midbrain (mb); hindbrain (hb; dermomyotome (dm); somites (s); interlimb somites (is). The approximate plane of sections J-N is shown in lower case letters in I.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

5936_wholemount__moderate.wlz

5936_wholemount__weak.wlz

5936_wholemount__possible.wlz

5936_wholemount__notDetected.wlz

5936_wholemount__strong.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:5936_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

trigeminal v ganglion

detected

facial vii ganglion

detected

acoustic viii ganglion

detected

dorsal root ganglion

detected

hindbrain

detected

midbrain

detected

neural tube

detected

regional

Expression along the length of the neural tube in lateral cells and the motor horn.

tail neural tube

detected

regional

Expression along the length of the neural tube in lateral cells and the motor horn.

otocyst

detected

Expression is seen in the epithelium of the otic vesicle

trunk somite

detected

regional

Expression is present at the inner surface of the dermomyotome (dm) in the ventro-caudal corner of the developing somites. Additional expression is seen in the ventral interlimb somites

genitourinary system

detected

regional

Expression detected in the epithelium underlying the urogenital ridge.

liver and biliary system

detected

regional

Expression in the epithelium of the hepatic primordium.

neural tube lateral wall

detected

Expression along the length of the neural tube in lateral cells and the motor horn.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:1967999
Entity Detected:	Lingo1, leucine rich repeat and Ig domain containing 1 ( MGI:1915522)
Sequence:	sense strand is shown >MGI:1967999 CTTGAGCGGATTCCTGCCCCCACCTGGTTACAGAATCTCCTTGTGCTTCAGGATTCGGTCAAGCATTGGA CCAATCACGTGCATGCTGAGACTGAGCCCCGAAGGCTGCTGTGTCCTCAGGCCTTTGGCAGCCCCTCTGC TTGGCTCCCTGTGCCATCTGACCCAGGAGTCACGTGAGCCTCCCTCTGGGATCTGGCATGAAGGAGAAAT GGATTCTGGCTTTCCCGCTCTGGCTTTCCCTGACTTCTCCAGAATCTAAGAAGTGTCCTGAGGCATCTCT TGCTCTACCTCAGCCCAGAATCCCTGAGGATCCATCCAGAAATCCAACGACTTCAAGACCTAAAAACATC AGGCCCCTCTCCCTGGACACAGACTTGACAGAAGTGGCCAGTTCATCAGGTGAGCGAGAGGATGCTGGCA GGGGGTATGAGAAGCATGCCCAGCCCCCTCCTGGCCTGCTGGCAGCCCATCCTCCTGCTGGTACTGGGCT CAGTGCTGTCAGGCTCTGCTACAGGCTGCCCGCCCCGCTGCGAGTGCTCAGCGCAGGACCGAGCCGTGCT CTGCCACCGCAAACGCTTTGTGGCGGTGCCCGAGGGCATCCCCACCGAGACTCGCCTGCTGGACCTGGGC AAAAACCGCATCAAGACACTCAACCAGGACGAGTTTGCCAGCTTCCCACACCTGGAGGAGCTAGAACTCA ATGAAAACATCGTGAGCGCCGTGGAGCCAGGCGCCTTCAACAACCTCTTCAACCTGAGGACTCTGGGGCT GCGCAGCAACCGCCTGA
	nt 1 - nt 787 of BC065696.1
Notes:	The Lingo1 (LERN1) probe used in this study by Haines & Rigby, 2008 [PMID:18297755] "was obtained from IMAGE clone 5685897. A clone for riboprobe synthesis was obtained by digesting with EcoRI and HindIII and ligating into pBluescipt II KS. An antisense probe was generated by digesting with EcoRI and transcribing with T3 RNA polymerase." Editor's note: IMAGE:5685897 was created by priming first strand cDNA synthesis with an oligo-dT primer containing a NotI site. Double stranded cDNA was subsequently ligated with an EcoRI adaptor, digested with NotI, and then cloned directionally into pYX-Asc vector. BC065696.1 is the full 2661bp insert sequence from IMAGE:5685897, which is cut by HindIII at position 787. pYX-Asc does not contain a HindIII site (see http://www.imagenes-bio.de/info/vectors/pYX-Asc.shtml). Therefore the EcoRI and HindIII cloned fragment corresponds to nt 1-787 of BC065696.1.
Chemistry:	RNA
Strand:	antisense
Label:	digoxigenin

Specimen

Organism:	mouse
Age:	10.5 dpc
Theiler Stage:	TS18
Mutations:	none (wild-type)
Preparation:	wholemount

Procedures

General Information

Authors:	Haines BP & Rigby PW, 2008 [PMID:18297755] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1016/j.modgep.2007.10.003] [ PMID:18297755] Haines BP, Rigby PW 2008 Expression of the Lingo/LERN gene family during mouse embryogenesis. Gene Expr Patterns (8):79-86
Links:	MGI:3789594 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source