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EMAGE:5945

Cthrc1 collagen triple helix repeat containing 1 ( MGI:1915838)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:5945
Fig1D. Copyright: Reprinted with permission from Cell Press from [doi:10.1016/j.devcel.2008.05.007] Dev Cell 15: 23-36, Yamamoto S; Nishimura O; Misaki K; Nishita M; Minami Y; Yonemura S; Tarui H; Sasaki H, "Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex." Copyright 2008 [PMID:18606138]

Expression pattern clarity: three stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Note: nc, notochord; vmb, ventral midbrain; dhb, dorsal hindbrain; ov, otic vesicle. Editors note: The structure that the authors denote as otic vesicle is not the otic vesicle as it is too anterior.
Expression Pattern Description
Spatial Annotation:
EMAGE:5945Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5945_wholemount__moderate.wlz
5945_wholemount__weak.wlz
5945_wholemount__notDetected.wlz
5945_wholemount__strong.wlz
5945_wholemount__possible.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5945_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: three stars
Text Annotation:
StructureLevelPatternNotes
future midbrain
detected detected
regionalExpression is present in the ventral midline.
future hindbrain
detected detected
regionalExpression is present in the dorsal hindbrain.
otocyst
detected detected
The authors state that expression is present in the otic vesicle however in Fig1D, the structure that the authors denote as the otic vesicle is not the otic vesicle as it is too anterior. However at the position of the otic vesicle in Fig1D, there does appear to be some expression evident.
notochord
detected detected
regionalExpression is present in the posterior notochord.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:3815428
Entity Detected:Cthrc1, collagen triple helix repeat containing 1 ( MGI:1915838)
Notes:The Cthrc1 probe used in this study by Yamamoto et al., 2008 [PMID:18606138] was obtained from a single node/notochord cell library from embryonic day (E) 8.5 mouse embryos. It is of unreported sequence.
Chemistry:RNA
Strand:antisense
Specimen
Organism:mouse
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Yamamoto S; Nishimura O; Misaki K; Nishita M; Minami Y; Yonemura S; Tarui H; Sasaki H, 2008 [PMID:18606138] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.devcel.2008.05.007] [ PMID:18606138] Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H 2008 Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (15):23-36
Links:MGI:3815436 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI